Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Ashley H Beecham; Nikolaos A Patsopoulos; Dionysia K Xifara; Mary F Davis; Anu Kemppinen; Chris Cotsapas; Tejas S Shah; Chris Spencer; David Booth; An Goris; Annette Oturai; Janna Saarela; Bertrand Fontaine; Bernhard Hemmer; Claes Martin; Frauke Zipp; Sandra D'Alfonso; Filippo Martinelli-Boneschi; Bruce Taylor; Hanne F Harbo; Ingrid Kockum; Jan Hillert; Tomas Olsson; Maria Ban; Jorge R Oksenberg; Rogier Hintzen; Lisa F Barcellos; Cristina Agliardi; Lars Alfredsson; Mehdi Alizadeh; Carl Anderson; Robert Andrews; Helle Bach Søndergaard; Amie Baker; Gavin Band; Sergio E Baranzini; Nadia Barizzone; Jeffrey Barrett; Céline Bellenguez; Laura Bergamaschi; Luisa Bernardinelli; Achim Berthele; Viola Biberacher; Thomas Binder; Hannah Blackburn; Izaura L Bomfim; Paola Brambilla; Simon Broadley; Finn Sellebjerg; Per Soelberg Sorensen; International Multiple Sclerosis Genetics Consortium (IMSGC)

doi:10.1038/ng.2770

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Ashley H Beecham, Nikolaos A Patsopoulos, Dionysia K Xifara, Mary F Davis, Anu Kemppinen, Chris Cotsapas, Tejas S Shah, Chris Spencer, David Booth, An Goris, Annette Oturai, Janna Saarela, Bertrand Fontaine, Bernhard Hemmer, Claes Martin, Frauke Zipp, Sandra D'Alfonso, Filippo Martinelli-Boneschi, Bruce Taylor, Hanne F HarboIngrid Kockum, Jan Hillert, Tomas Olsson, Maria Ban, Jorge R Oksenberg, Rogier Hintzen, Lisa F Barcellos, Cristina Agliardi, Lars Alfredsson, Mehdi Alizadeh, Carl Anderson, Robert Andrews, Helle Bach Søndergaard, Amie Baker, Gavin Band, Sergio E Baranzini, Nadia Barizzone, Jeffrey Barrett, Céline Bellenguez, Laura Bergamaschi, Luisa Bernardinelli, Achim Berthele, Viola Biberacher, Thomas Binder, Hannah Blackburn, Izaura L Bomfim, Paola Brambilla, Simon Broadley, Finn Sellebjerg, Per Soelberg Sorensen, International Multiple Sclerosis Genetics Consortium (IMSGC)

Department of Neurology

1081 Citations (Scopus)

Abstract

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P

Original language	English
Journal	Nature Genetics
Volume	45
Issue number	11
Pages (from-to)	1353-60
Number of pages	8
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.2770
Publication status	Published - Nov 2013

Keywords

Chromosome Mapping
European Continental Ancestry Group
Gene Frequency
Genetic Loci
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genotype
Humans
Multiple Sclerosis
Polymorphism, Single Nucleotide

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Beecham, A. H., Patsopoulos, N. A., Xifara, D. K., Davis, M. F., Kemppinen, A., Cotsapas, C., Shah, T. S., Spencer, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., Hemmer, B., Martin, C., Zipp, F., D'Alfonso, S., Martinelli-Boneschi, F., Taylor, B., ... International Multiple Sclerosis Genetics Consortium (IMSGC) (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics, 45(11), 1353-60. https://doi.org/10.1038/ng.2770

Beecham, AH, Patsopoulos, NA, Xifara, DK, Davis, MF, Kemppinen, A, Cotsapas, C, Shah, TS, Spencer, C, Booth, D, Goris, A, Oturai, A, Saarela, J, Fontaine, B, Hemmer, B, Martin, C, Zipp, F, D'Alfonso, S, Martinelli-Boneschi, F, Taylor, B, Harbo, HF, Kockum, I, Hillert, J, Olsson, T, Ban, M, Oksenberg, JR, Hintzen, R, Barcellos, LF, Agliardi, C, Alfredsson, L, Alizadeh, M, Anderson, C, Andrews, R, Søndergaard, HB, Baker, A, Band, G, Baranzini, SE, Barizzone, N, Barrett, J, Bellenguez, C, Bergamaschi, L, Bernardinelli, L, Berthele, A, Biberacher, V, Binder, T, Blackburn, H, Bomfim, IL, Brambilla, P, Broadley, S, Sellebjerg, F , Sorensen, PS & International Multiple Sclerosis Genetics Consortium (IMSGC) 2013, 'Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis', Nature Genetics, vol. 45, no. 11, pp. 1353-60. https://doi.org/10.1038/ng.2770

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abstract = "Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P ",

keywords = "Chromosome Mapping, European Continental Ancestry Group, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Multiple Sclerosis, Polymorphism, Single Nucleotide",

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AU - Shah, Tejas S

AU - Spencer, Chris

AU - Booth, David

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AU - Oturai, Annette

AU - Saarela, Janna

AU - Fontaine, Bertrand

AU - Hemmer, Bernhard

AU - Martin, Claes

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AU - Martinelli-Boneschi, Filippo

AU - Taylor, Bruce

AU - Harbo, Hanne F

AU - Kockum, Ingrid

AU - Hillert, Jan

AU - Olsson, Tomas

AU - Ban, Maria

AU - Oksenberg, Jorge R

AU - Hintzen, Rogier

AU - Barcellos, Lisa F

AU - Agliardi, Cristina

AU - Alfredsson, Lars

AU - Alizadeh, Mehdi

AU - Anderson, Carl

AU - Andrews, Robert

AU - Søndergaard, Helle Bach

AU - Baker, Amie

AU - Band, Gavin

AU - Baranzini, Sergio E

AU - Barizzone, Nadia

AU - Barrett, Jeffrey

AU - Bellenguez, Céline

AU - Bergamaschi, Laura

AU - Bernardinelli, Luisa

AU - Berthele, Achim

AU - Biberacher, Viola

AU - Binder, Thomas

AU - Blackburn, Hannah

AU - Bomfim, Izaura L

AU - Brambilla, Paola

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AU - Sellebjerg, Finn

AU - Sorensen, Per Soelberg

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KW - Chromosome Mapping

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KW - Gene Frequency

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Multiple Sclerosis

KW - Polymorphism, Single Nucleotide

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DO - 10.1038/ng.2770

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JO - Nature Genetics

JF - Nature Genetics

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ER -

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Abstract

Keywords

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