Anakinra alters epidermal tissue-resident memory T-cell profiles but fails to reduce clinical responses upon nickel rechallenge in individuals with nickel allergy

Kelvin Yeung; Julie F. Weber; Simone M. Stegenborg-Grathwohl; Tu Hu; Anders B. Funch; Christopher W. Schwarz; Veronika Mraz; Helen Vaher; Anne Sofie Ø. Gadsbøll; Mia Hamilton Jee; Claus Zachariae; Carsten Geisler; Lone Skov; Charlotte M. Bonefeld

doi:10.1016/j.jid.2026.04.027

Anakinra alters epidermal tissue-resident memory T-cell profiles but fails to reduce clinical responses upon nickel rechallenge in individuals with nickel allergy

Kelvin Yeung
, Julie F. Weber
, Simone M. Stegenborg-Grathwohl
, Tu Hu
, Anders B. Funch
, Christopher W. Schwarz
, Veronika Mraz
, Helen Vaher
, Anne Sofie Ø. Gadsbøll
, Mia Hamilton Jee
, Claus Zachariae
, Carsten Geisler
, Lone Skov
, Charlotte M. Bonefeld^*

^*Corresponding author for this work

Dermatology and Allergy

Original language	English
Journal	Journal of Investigative Dermatology
ISSN	0022-202X
DOIs	https://doi.org/10.1016/j.jid.2026.04.027
Publication status	E-pub ahead of print - 8 May 2026

Keywords

Allergy
Contact allergen
IL-1
Immunology
T cell

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10.1016/j.jid.2026.04.027Licence: CC BY

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Yeung, K., Weber, J. F., Stegenborg-Grathwohl, S. M., Hu, T., Funch, A. B., Schwarz, C. W., Mraz, V., Vaher, H., Gadsbøll, A. S. Ø., Jee, M. H., Zachariae, C., Geisler, C., Skov, L., & Bonefeld, C. M. (2026). Anakinra alters epidermal tissue-resident memory T-cell profiles but fails to reduce clinical responses upon nickel rechallenge in individuals with nickel allergy. Journal of Investigative Dermatology. Advance online publication. https://doi.org/10.1016/j.jid.2026.04.027

Yeung, K, Weber, JF, Stegenborg-Grathwohl, SM, Hu, T, Funch, AB, Schwarz, CW, Mraz, V, Vaher, H, Gadsbøll, ASØ, Jee, MH, Zachariae, C, Geisler, C, Skov, L & Bonefeld, CM 2026, 'Anakinra alters epidermal tissue-resident memory T-cell profiles but fails to reduce clinical responses upon nickel rechallenge in individuals with nickel allergy', Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2026.04.027

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title = "Anakinra alters epidermal tissue-resident memory T-cell profiles but fails to reduce clinical responses upon nickel rechallenge in individuals with nickel allergy",

keywords = "Allergy, Contact allergen, IL-1, Immunology, T cell",

author = "Kelvin Yeung and Weber, \{Julie F.\} and Stegenborg-Grathwohl, \{Simone M.\} and Tu Hu and Funch, \{Anders B.\} and Schwarz, \{Christopher W.\} and Veronika Mraz and Helen Vaher and Gadsb{\o}ll, \{Anne Sofie {\O}.\} and Jee, \{Mia Hamilton\} and Claus Zachariae and Carsten Geisler and Lone Skov and Bonefeld, \{Charlotte M.\}",

year = "2026",

month = may,

day = "8",

doi = "10.1016/j.jid.2026.04.027",

language = "English",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

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T1 - Anakinra alters epidermal tissue-resident memory T-cell profiles but fails to reduce clinical responses upon nickel rechallenge in individuals with nickel allergy

AU - Yeung, Kelvin

AU - Weber, Julie F.

AU - Stegenborg-Grathwohl, Simone M.

AU - Hu, Tu

AU - Funch, Anders B.

AU - Schwarz, Christopher W.

AU - Mraz, Veronika

AU - Vaher, Helen

AU - Gadsbøll, Anne Sofie Ø.

AU - Jee, Mia Hamilton

AU - Zachariae, Claus

AU - Geisler, Carsten

AU - Skov, Lone

AU - Bonefeld, Charlotte M.

PY - 2026/5/8

Y1 - 2026/5/8

KW - Allergy

KW - Contact allergen

KW - IL-1

KW - Immunology

KW - T cell

UR - https://www.scopus.com/pages/publications/105040622277

U2 - 10.1016/j.jid.2026.04.027

DO - 10.1016/j.jid.2026.04.027

M3 - Letter

C2 - 42107492

AN - SCOPUS:105040622277

SN - 0022-202X

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

ER -

Anakinra alters epidermal tissue-resident memory T-cell profiles but fails to reduce clinical responses upon nickel rechallenge in individuals with nickel allergy

Keywords

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