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An update on cirrhotic cardiomyopathy

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INTRODUCTION: Cirrhosis with portal hypertension and related complications are associated with a high mortality. Excess of circulating vasodilatators and cardiodepressive substances lead to a hyperdynamic circulation with changed myocardial structure and function. The entity cirrhotic cardiomyopathy seems to be involved in different aspects of hepatic decompensation, which focuses on new targets of treatment. Areas covered: This review deals with contemporary aspects of cirrhotic cardiomyopathy and the literature search was undertaken by PubMed with "cirrhotic" and "cardiomyopathies" as MeSH Terms. Cirrhotic cardiomyopathy is defined as presence of systolic and diastolic dysfunction and electrophysiological abnormalities. The diagnosis is based on contemporary Doppler/Echocardiography measurements or quatitative magnetic resonance imaging. Cirrhotic cardiomyopathy is independent of the etiology of the liver disease but related to severity and survival. Expert opinion: The outcome of invasive procedures and liver transplantation is influenced by presence of cardiac dysfunction. Therefore, a cautious cardiac evaluation should be included in the patient evaluation prior to liver transplantation. Liver transplantation ameliorates most of the abnormalities seen in cirrhotic cardiomyopathy, but no specific treatment can yet be recommended.

Original languageEnglish
JournalExpert review of gastroenterology & hepatology
Volume13
Issue number5
Pages (from-to)497-505
Number of pages9
ISSN1747-4124
DOIs
Publication statusPublished - May 2019

    Research areas

  • arterial vasodilatation, cardiovascular dysfunction, cirrhosis, Cirrhotic cardiomyopathy, diastolic dysfunction, heart failure, hyperdynamic circulation, liver transplantation, portal hypertension, QT-interval, systolic dysfunction

ID: 56740179