An international perspective on hospitalized patients with viral community-acquired pneumonia

Dejan Radovanovic; Giovanni Sotgiu; Mateja Jankovic; Padukudru Anand Mahesh; Pedro Jorge Marcos; Mohamed I Abdalla; Marta Francesca Di Pasquale; Andrea Gramegna; Silvia Terraneo; Francesco Blasi; Pierachille Santus; Stefano Aliberti; Luis F Reyes; Marcos I Restrepo; Patricia Karina Aruj; Silvia Attorri; Enrique Barimboim; Juan Pablo Caeiro; María I Garzón; Victor Hugo Cambursano; Adrian Ceccato; Julio Chertcoff; Ariel Cordon Díaz; Lautaro de Vedia; Maria Cristina Ganaha; Sandra Lambert; Gustavo Lopardo; Carlos M Luna; Alessio Gerardo Malberti; Nora Morcillo; Silvina Tartara; Claudia Pensotti; Betiana Pereyra; Pablo Gustavo Scapellato; Juan Pablo Stagnaro; Sonali Shah; Felix Lötsch; Florian Thalhammer; Kurt Anseeuw; Camille A Francois; Eva Van Braeckel; Jean Louis Vincent; Marcel Zannou Djimon; Simone Aranha Nouér; Peter Chipev; Milena Encheva; Darina Miteva; Diana Petkova; GLIMP Study Group; Marie-Laure Bouchy Jacobsson; Andreas Vestergaard Jensen; Gertrud  Baunbæk Egelund; Pelle Trier Petersen; Stine Andersen

doi:10.1016/j.ejim.2018.10.020

An international perspective on hospitalized patients with viral community-acquired pneumonia

Dejan Radovanovic, Giovanni Sotgiu, Mateja Jankovic, Padukudru Anand Mahesh, Pedro Jorge Marcos, Mohamed I Abdalla, Marta Francesca Di Pasquale, Andrea Gramegna, Silvia Terraneo, Francesco Blasi, Pierachille Santus, Stefano Aliberti, Luis F Reyes, Marcos I Restrepo, Patricia Karina Aruj, Silvia Attorri, Enrique Barimboim, Juan Pablo Caeiro, María I Garzón, Victor Hugo CambursanoAdrian Ceccato, Julio Chertcoff, Ariel Cordon Díaz, Lautaro de Vedia, Maria Cristina Ganaha, Sandra Lambert, Gustavo Lopardo, Carlos M Luna, Alessio Gerardo Malberti, Nora Morcillo, Silvina Tartara, Claudia Pensotti, Betiana Pereyra, Pablo Gustavo Scapellato, Juan Pablo Stagnaro, Sonali Shah, Felix Lötsch, Florian Thalhammer, Kurt Anseeuw, Camille A Francois, Eva Van Braeckel, Jean Louis Vincent, Marcel Zannou Djimon, Simone Aranha Nouér, Peter Chipev, Milena Encheva, Darina Miteva, Diana Petkova, GLIMP Study Group, Marie-Laure Bouchy Jacobsson (Member of study group), Andreas Vestergaard Jensen (Member of study group), Gertrud Baunbæk Egelund (Member of study group), Pelle Trier Petersen (Member of study group), Stine Andersen (Member of study group)

25 Citations (Scopus)

Abstract

BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.

METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.

RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.

CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

Original language	English
Journal	European Journal of Internal Medicine
Volume	60
Pages (from-to)	54-70
Number of pages	17
ISSN	0953-6205
DOIs	https://doi.org/10.1016/j.ejim.2018.10.020
Publication status	Published - 2019

Keywords

Community acquired pneumonia
Influenza
Oseltamivir
Testing
Viral pneumonia
Viral swab

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10.1016/j.ejim.2018.10.020

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Radovanovic, D., Sotgiu, G., Jankovic, M., Mahesh, P. A., Marcos, P. J., Abdalla, M. I., Di Pasquale, M. F., Gramegna, A., Terraneo, S., Blasi, F., Santus, P., Aliberti, S., Reyes, L. F., Restrepo, M. I., Aruj, P. K., Attorri, S., Barimboim, E., Caeiro, J. P., Garzón, M. I., ... Andersen, S. (2019). An international perspective on hospitalized patients with viral community-acquired pneumonia. European Journal of Internal Medicine, 60, 54-70. https://doi.org/10.1016/j.ejim.2018.10.020

Radovanovic, D, Sotgiu, G, Jankovic, M, Mahesh, PA, Marcos, PJ, Abdalla, MI, Di Pasquale, MF, Gramegna, A, Terraneo, S, Blasi, F, Santus, P, Aliberti, S, Reyes, LF, Restrepo, MI, Aruj, PK, Attorri, S, Barimboim, E, Caeiro, JP, Garzón, MI, Cambursano, VH, Ceccato, A, Chertcoff, J, Cordon Díaz, A, de Vedia, L, Ganaha, MC, Lambert, S, Lopardo, G, Luna, CM, Malberti, AG, Morcillo, N, Tartara, S, Pensotti, C, Pereyra, B, Scapellato, PG, Stagnaro, JP, Shah, S, Lötsch, F, Thalhammer, F, Anseeuw, K, Francois, CA, Van Braeckel, E, Vincent, JL, Djimon, MZ, Aranha Nouér, S, Chipev, P, Encheva, M, Miteva, D, Petkova, D, GLIMP Study Group, Bouchy Jacobsson, M-L, Vestergaard Jensen, A , Baunbæk Egelund, G , Trier Petersen, P & Andersen, S 2019, 'An international perspective on hospitalized patients with viral community-acquired pneumonia', European Journal of Internal Medicine, vol. 60, pp. 54-70. https://doi.org/10.1016/j.ejim.2018.10.020

@article{316d7fe663a847dca30f7c192b46e6a4,

title = "An international perspective on hospitalized patients with viral community-acquired pneumonia",

abstract = "BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.",

keywords = "Community acquired pneumonia, Influenza, Oseltamivir, Testing, Viral pneumonia, Viral swab",

author = "Dejan Radovanovic and Giovanni Sotgiu and Mateja Jankovic and Mahesh, {Padukudru Anand} and Marcos, {Pedro Jorge} and Abdalla, {Mohamed I} and {Di Pasquale}, {Marta Francesca} and Andrea Gramegna and Silvia Terraneo and Francesco Blasi and Pierachille Santus and Stefano Aliberti and Reyes, {Luis F} and Restrepo, {Marcos I} and Aruj, {Patricia Karina} and Silvia Attorri and Enrique Barimboim and Caeiro, {Juan Pablo} and Garz{\'o}n, {Mar{\'i}a I} and Cambursano, {Victor Hugo} and Adrian Ceccato and Julio Chertcoff and {Cordon D{\'i}az}, Ariel and {de Vedia}, Lautaro and Ganaha, {Maria Cristina} and Sandra Lambert and Gustavo Lopardo and Luna, {Carlos M} and Malberti, {Alessio Gerardo} and Nora Morcillo and Silvina Tartara and Claudia Pensotti and Betiana Pereyra and Scapellato, {Pablo Gustavo} and Stagnaro, {Juan Pablo} and Sonali Shah and Felix L{\"o}tsch and Florian Thalhammer and Kurt Anseeuw and Francois, {Camille A} and {Van Braeckel}, Eva and Vincent, {Jean Louis} and Djimon, {Marcel Zannou} and {Aranha Nou{\'e}r}, Simone and Peter Chipev and Milena Encheva and Darina Miteva and Diana Petkova and {GLIMP Study Group} and {Bouchy Jacobsson}, Marie-Laure and {Vestergaard Jensen}, Andreas and {Baunb{\ae}k Egelund}, Gertrud and {Trier Petersen}, Pelle and Stine Andersen",

year = "2019",

doi = "10.1016/j.ejim.2018.10.020",

language = "English",

volume = "60",

pages = "54--70",

journal = "European Journal of Internal Medicine",

issn = "0953-6205",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - An international perspective on hospitalized patients with viral community-acquired pneumonia

AU - Radovanovic, Dejan

AU - Sotgiu, Giovanni

AU - Jankovic, Mateja

AU - Mahesh, Padukudru Anand

AU - Marcos, Pedro Jorge

AU - Abdalla, Mohamed I

AU - Di Pasquale, Marta Francesca

AU - Gramegna, Andrea

AU - Terraneo, Silvia

AU - Blasi, Francesco

AU - Santus, Pierachille

AU - Aliberti, Stefano

AU - Reyes, Luis F

AU - Restrepo, Marcos I

AU - Aruj, Patricia Karina

AU - Attorri, Silvia

AU - Barimboim, Enrique

AU - Caeiro, Juan Pablo

AU - Garzón, María I

AU - Cambursano, Victor Hugo

AU - Ceccato, Adrian

AU - Chertcoff, Julio

AU - Cordon Díaz, Ariel

AU - de Vedia, Lautaro

AU - Ganaha, Maria Cristina

AU - Lambert, Sandra

AU - Lopardo, Gustavo

AU - Luna, Carlos M

AU - Malberti, Alessio Gerardo

AU - Morcillo, Nora

AU - Tartara, Silvina

AU - Pensotti, Claudia

AU - Pereyra, Betiana

AU - Scapellato, Pablo Gustavo

AU - Stagnaro, Juan Pablo

AU - Shah, Sonali

AU - Lötsch, Felix

AU - Thalhammer, Florian

AU - Anseeuw, Kurt

AU - Francois, Camille A

AU - Van Braeckel, Eva

AU - Vincent, Jean Louis

AU - Djimon, Marcel Zannou

AU - Aranha Nouér, Simone

AU - Chipev, Peter

AU - Encheva, Milena

AU - Miteva, Darina

AU - Petkova, Diana

AU - GLIMP Study Group

A2 - Bouchy Jacobsson, Marie-Laure

A2 - Vestergaard Jensen, Andreas

A2 - Baunbæk Egelund, Gertrud

A2 - Trier Petersen, Pelle

A2 - Andersen, Stine

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

AB - BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

KW - Community acquired pneumonia

KW - Influenza

KW - Oseltamivir

KW - Testing

KW - Viral pneumonia

KW - Viral swab

UR - http://www.scopus.com/inward/record.url?scp=85055913331&partnerID=8YFLogxK

U2 - 10.1016/j.ejim.2018.10.020

DO - 10.1016/j.ejim.2018.10.020

M3 - Journal article

C2 - 30401576

SN - 0953-6205

VL - 60

SP - 54

EP - 70

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

ER -

An international perspective on hospitalized patients with viral community-acquired pneumonia

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