An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells

Gianpaolo Papaccio, Ferdinando Nicoletti, Francesco A Pisanti, Michela Galdieri, Klaus Bendtzen

    17 Citations (Scopus)

    Abstract

    In vitro studies have demonstrated that interleukin (IL)-1beta decreases insulin and DNA contents in pancreatic islet beta cells, causing structural damage, that it is toxic to cultured human islet beta cells and that it is able to induce apoptosis in these cells.
    Original languageEnglish
    JournalMolecular Medicine
    Volume8
    Issue number9
    Pages (from-to)536-45
    Number of pages10
    ISSN1076-1551
    Publication statusPublished - 1 Sept 2002

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