An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

Unn Kristin Haukvik; Peter Saetre; Thomas McNeil; Petr S Bjerkan; Ole A Andreassen; Thomas Werge; Erik G Jönsson; Ingrid Agartz

doi:10.1016/j.pnpbp.2010.07.001

An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

Unn Kristin Haukvik, Peter Saetre, Thomas McNeil, Petr S Bjerkan, Ole A Andreassen, Thomas Werge, Erik G Jönsson, Ingrid Agartz

34 Citations (Scopus)

Abstract

Smaller hippocampal volume has repeatedly been reported in schizophrenia patients. Obstetric complications (OCs) and single nucleotide polymorphism (SNP) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume. We investigated putative independent and interaction effects of severe hypoxia-related OCs and variation in four hypoxia-regulated schizophrenia susceptibility genes (BDNF, DTNBP1, GRM3 and NRG1) on hippocampal volume in schizophrenia patients and healthy controls.

Original language	English
Journal	Progress in neuro-psychopharmacology & biological psychiatry
Volume	34
Issue number	7
Pages (from-to)	1259-65
Number of pages	7
DOIs	https://doi.org/10.1016/j.pnpbp.2010.07.001
Publication status	Published - 1 Oct 2010

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Haukvik, U. K., Saetre, P., McNeil, T., Bjerkan, P. S., Andreassen, O. A., Werge, T., Jönsson, E. G., & Agartz, I. (2010). An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. Progress in neuro-psychopharmacology & biological psychiatry, 34(7), 1259-65. https://doi.org/10.1016/j.pnpbp.2010.07.001

An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. / Haukvik, Unn Kristin; Saetre, Peter; McNeil, Thomas et al.
In: Progress in neuro-psychopharmacology & biological psychiatry, Vol. 34, No. 7, 01.10.2010, p. 1259-65.

Research output: Contribution to journal › Journal article › Research › peer-review

Haukvik, UK, Saetre, P, McNeil, T, Bjerkan, PS, Andreassen, OA, Werge, T, Jönsson, EG & Agartz, I 2010, 'An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes', Progress in neuro-psychopharmacology & biological psychiatry, vol. 34, no. 7, pp. 1259-65. https://doi.org/10.1016/j.pnpbp.2010.07.001

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An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

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