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The Capital Region of Denmark - a part of Copenhagen University Hospital
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An effect from anticipation also in hereditary nonpolyposis colorectal cancer families without identified mutations

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  1. Parental occupational organic dust exposure and selected childhood cancers in Denmark 1968-2016

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  2. Rational targeting of population groups and residential areas for colorectal cancer screening

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  3. Answer to: "Is the National Danish Colorectal Cancer Screening Programme a success?"

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  1. Use of primary health care and participation in colorectal cancer screening - a Danish national register-based study

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  2. Benefit from extended surveillance interval on colorectal cancer risk in Lynch syndrome

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  3. Broadening risk profile in familial colorectal cancer type X; increased risk for five cancer types in the national Danish cohort

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  4. Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge

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  5. Difficult journeys in sarcoma care; socioeconomic disparity added to the multiple challenges of a rare tumor diagnosis

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Optimal prevention of hereditary cancer is central and requires initiation of surveillance programmes and/or prophylactic measures at a safe age. Anticipation, expressed as an earlier age at onset in successive generations, has been demonstrated in hereditary nonpolyposis colorectal cancer (HNPCC). We specifically addressed anticipation in phenotypic HNPCC families without disease-predisposing mismatch repair (MMR) defects since risk estimates and age at onset are particularly difficult to determine in this cohort. The national Danish HNPCC register was used to identify families who fulfilled the Amsterdam criteria for HNPCC and showed normal MMR function and/or lack of disease-predisposing MMR gene mutation. In total, 319 cancers from 212 parent-child pairs in 99 families were identified. A paired t-test and a bivariate statistical model were used to assess anticipation. Both methods demonstrated an effect from anticipation with cancer diagnosed mean 11.4 years (t-test, p<0.0001) and mean 5.9 (bivariate model, p=0.02) years earlier in children than in parents. This observation suggests that anticipation may apply also to families without identified mutations and serves as a reminder to initiate surveillance programmes at young age also in HNPCC families with undefined genetic causes.
Original languageEnglish
JournalCancer epidemiology
Volume33
Issue number3-4
Pages (from-to)231-4
Number of pages3
DOIs
Publication statusPublished - 2009

ID: 32564870