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The Capital Region of Denmark - a part of Copenhagen University Hospital
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An allosteric enhancer of M(4) muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

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  1. Correction to: Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys

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  2. Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study

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  3. Tryptophan depletion affects compulsive behaviour in rats: strain dependent effects and associated neuromechanisms

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  1. The effect of erythropoietin on electroconvulsive stimulation induced cognitive impairment in rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Correction to: Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

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  4. Clinical association to FKBP5 rs1360780 in patients with depression

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The mesostriatal dopamine system plays a key role in mediating the reinforcing effects of psychostimulant drugs like cocaine. The muscarinic M(4) acetylcholine receptor subtype is centrally involved in the regulation of dopamine release in striatal areas. Consequently, striatal M(4) receptors could be a novel target for modulating psychostimulant effects of cocaine.
Original languageEnglish
JournalPsychopharmacology
Volume224
Issue number2
Pages (from-to)277-87
Number of pages11
ISSN0033-3158
DOIs
Publication statusPublished - 2012

ID: 36474347