Ambient air pollution triggers wheezing symptoms in infants

Z J Andersen; S Loft; M Ketzel; M Stage; T Scheike; M N Hermansen; H Bisgaard

doi:10.1136/thx.2007.085480

Ambient air pollution triggers wheezing symptoms in infants

Z J Andersen
, S Loft
, M Ketzel
, M Stage
, T Scheike
, M N Hermansen
, H Bisgaard

Dermatology and Allergy

99 Citations (Scopus)

Abstract

BACKGROUND: There is limited evidence for the role of air pollution in the development and triggering of wheezing symptoms in young children. A study was undertaken to examine the effect of exposure to air pollution on wheezing symptoms in children under the age of 3 years with genetic susceptibility to asthma.

METHODS: Daily recordings of symptoms were obtained for 205 children participating in the birth cohort study Copenhagen Prospective Study on Asthma in Children and living in Copenhagen for the first 3 years of life. Daily air pollution levels for particulate matter <10 microm in diameter (PM(10)) and the concentrations of ultrafine particles, nitrogen dioxide (NO(2)), nitrogen oxide (NO(x)) and carbon monoxide (CO) were available from a central background monitoring station in Copenhagen. The association between incident wheezing symptoms and air pollution on the concurrent and previous 4 days was estimated by a logistic regression model (generalised estimating equation) controlling for temperature, season, gender, age, exposure to smoking and paternal history of asthma.

RESULTS: Significant positive associations were found between concentrations of PM(10), NO(2), NO(x), CO and wheezing symptoms in infants (aged 0-1 year) with a delay of 3-4 days. Only the traffic-related gases (NO(2), NO(x)) showed significant effects throughout the 3 years of life, albeit attenuating after the age of 1 year.

CONCLUSIONS: Air pollution related to traffic is significantly associated with triggering of wheezing symptoms in the first 3 years of life.

Original language	English
Journal	Thorax
Volume	63
Issue number	8
Pages (from-to)	710-6
Number of pages	7
ISSN	0040-6376
DOIs	https://doi.org/10.1136/thx.2007.085480
Publication status	Published - Aug 2008

Keywords

Air Pollutants
Air Pollution
Asthma
Carbon Monoxide
Child, Preschool
Denmark
Epidemiologic Methods
Female
Genetic Predisposition to Disease
Humans
Infant
Male
Nitrogen Dioxide
Nitrogen Oxides
Particulate Matter
Pedigree
Prospective Studies
Respiratory Sounds
Time Factors
Vehicle Emissions

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10.1136/thx.2007.085480

Cite this

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title = "Ambient air pollution triggers wheezing symptoms in infants",

abstract = "BACKGROUND: There is limited evidence for the role of air pollution in the development and triggering of wheezing symptoms in young children. A study was undertaken to examine the effect of exposure to air pollution on wheezing symptoms in children under the age of 3 years with genetic susceptibility to asthma.METHODS: Daily recordings of symptoms were obtained for 205 children participating in the birth cohort study Copenhagen Prospective Study on Asthma in Children and living in Copenhagen for the first 3 years of life. Daily air pollution levels for particulate matter <10 microm in diameter (PM(10)) and the concentrations of ultrafine particles, nitrogen dioxide (NO(2)), nitrogen oxide (NO(x)) and carbon monoxide (CO) were available from a central background monitoring station in Copenhagen. The association between incident wheezing symptoms and air pollution on the concurrent and previous 4 days was estimated by a logistic regression model (generalised estimating equation) controlling for temperature, season, gender, age, exposure to smoking and paternal history of asthma.RESULTS: Significant positive associations were found between concentrations of PM(10), NO(2), NO(x), CO and wheezing symptoms in infants (aged 0-1 year) with a delay of 3-4 days. Only the traffic-related gases (NO(2), NO(x)) showed significant effects throughout the 3 years of life, albeit attenuating after the age of 1 year.CONCLUSIONS: Air pollution related to traffic is significantly associated with triggering of wheezing symptoms in the first 3 years of life.",

keywords = "Air Pollutants, Air Pollution, Asthma, Carbon Monoxide, Child, Preschool, Denmark, Epidemiologic Methods, Female, Genetic Predisposition to Disease, Humans, Infant, Male, Nitrogen Dioxide, Nitrogen Oxides, Particulate Matter, Pedigree, Prospective Studies, Respiratory Sounds, Time Factors, Vehicle Emissions",

author = "Andersen, \{Z J\} and S Loft and M Ketzel and M Stage and T Scheike and Hermansen, \{M N\} and H Bisgaard",

year = "2008",

month = aug,

doi = "10.1136/thx.2007.085480",

language = "English",

volume = "63",

pages = "710--6",

journal = "Thorax",

issn = "0040-6376",

publisher = "BMJ Publishing Group",

number = "8",

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TY - JOUR

T1 - Ambient air pollution triggers wheezing symptoms in infants

AU - Andersen, Z J

AU - Loft, S

AU - Ketzel, M

AU - Stage, M

AU - Scheike, T

AU - Hermansen, M N

AU - Bisgaard, H

PY - 2008/8

Y1 - 2008/8

N2 - BACKGROUND: There is limited evidence for the role of air pollution in the development and triggering of wheezing symptoms in young children. A study was undertaken to examine the effect of exposure to air pollution on wheezing symptoms in children under the age of 3 years with genetic susceptibility to asthma.METHODS: Daily recordings of symptoms were obtained for 205 children participating in the birth cohort study Copenhagen Prospective Study on Asthma in Children and living in Copenhagen for the first 3 years of life. Daily air pollution levels for particulate matter <10 microm in diameter (PM(10)) and the concentrations of ultrafine particles, nitrogen dioxide (NO(2)), nitrogen oxide (NO(x)) and carbon monoxide (CO) were available from a central background monitoring station in Copenhagen. The association between incident wheezing symptoms and air pollution on the concurrent and previous 4 days was estimated by a logistic regression model (generalised estimating equation) controlling for temperature, season, gender, age, exposure to smoking and paternal history of asthma.RESULTS: Significant positive associations were found between concentrations of PM(10), NO(2), NO(x), CO and wheezing symptoms in infants (aged 0-1 year) with a delay of 3-4 days. Only the traffic-related gases (NO(2), NO(x)) showed significant effects throughout the 3 years of life, albeit attenuating after the age of 1 year.CONCLUSIONS: Air pollution related to traffic is significantly associated with triggering of wheezing symptoms in the first 3 years of life.

AB - BACKGROUND: There is limited evidence for the role of air pollution in the development and triggering of wheezing symptoms in young children. A study was undertaken to examine the effect of exposure to air pollution on wheezing symptoms in children under the age of 3 years with genetic susceptibility to asthma.METHODS: Daily recordings of symptoms were obtained for 205 children participating in the birth cohort study Copenhagen Prospective Study on Asthma in Children and living in Copenhagen for the first 3 years of life. Daily air pollution levels for particulate matter <10 microm in diameter (PM(10)) and the concentrations of ultrafine particles, nitrogen dioxide (NO(2)), nitrogen oxide (NO(x)) and carbon monoxide (CO) were available from a central background monitoring station in Copenhagen. The association between incident wheezing symptoms and air pollution on the concurrent and previous 4 days was estimated by a logistic regression model (generalised estimating equation) controlling for temperature, season, gender, age, exposure to smoking and paternal history of asthma.RESULTS: Significant positive associations were found between concentrations of PM(10), NO(2), NO(x), CO and wheezing symptoms in infants (aged 0-1 year) with a delay of 3-4 days. Only the traffic-related gases (NO(2), NO(x)) showed significant effects throughout the 3 years of life, albeit attenuating after the age of 1 year.CONCLUSIONS: Air pollution related to traffic is significantly associated with triggering of wheezing symptoms in the first 3 years of life.

KW - Air Pollutants

KW - Air Pollution

KW - Asthma

KW - Carbon Monoxide

KW - Child, Preschool

KW - Denmark

KW - Epidemiologic Methods

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Infant

KW - Male

KW - Nitrogen Dioxide

KW - Nitrogen Oxides

KW - Particulate Matter

KW - Pedigree

KW - Prospective Studies

KW - Respiratory Sounds

KW - Time Factors

KW - Vehicle Emissions

U2 - 10.1136/thx.2007.085480

DO - 10.1136/thx.2007.085480

M3 - Journal article

C2 - 18267985

SN - 0040-6376

VL - 63

SP - 710

EP - 716

JO - Thorax

JF - Thorax

IS - 8

ER -

Ambient air pollution triggers wheezing symptoms in infants

Abstract

Keywords

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