Alveolar inflammation in cystic fibrosis

Martina Ulrich; Dieter Worlitzsch; Simona Viglio; Nanna Siegmann; Paolo Iadarola; Janis K Shute; Marianne Geiser; Gerald B Pier; Godehard Friedel; Mark L Barr; Antje Schuster; Keith C Meyer; Felix Ratjen; Thomas Bjarnsholt; Erich Gulbins; Gerd Döring

doi:10.1016/j.jcf.2010.03.001

Alveolar inflammation in cystic fibrosis

Martina Ulrich, Dieter Worlitzsch, Simona Viglio, Nanna Siegmann, Paolo Iadarola, Janis K Shute, Marianne Geiser, Gerald B Pier, Godehard Friedel, Mark L Barr, Antje Schuster, Keith C Meyer, Felix Ratjen, Thomas Bjarnsholt, Erich Gulbins, Gerd Döring

Department of Clinical Microbiology

107 Citations (Scopus)

Abstract

In infected lungs of the cystic fibrosis (CF) patients, opportunistic pathogens and mutated cystic fibrosis transmembrane conductance regulator protein (CFTR) contribute to chronic airway inflammation that is characterized by neutrophil/macrophage infiltration, cytokine release and ceramide accumulation. We sought to investigate CF lung inflammation in the alveoli.

Original language	English
Journal	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume	9
Issue number	3
Pages (from-to)	217-27
Number of pages	11
DOIs	https://doi.org/10.1016/j.jcf.2010.03.001
Publication status	Published - 1 May 2010

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10.1016/j.jcf.2010.03.001

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Ulrich, M., Worlitzsch, D., Viglio, S., Siegmann, N., Iadarola, P., Shute, J. K., Geiser, M., Pier, G. B., Friedel, G., Barr, M. L., Schuster, A., Meyer, K. C., Ratjen, F., Bjarnsholt, T., Gulbins, E., & Döring, G. (2010). Alveolar inflammation in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 9(3), 217-27. https://doi.org/10.1016/j.jcf.2010.03.001

Ulrich, M, Worlitzsch, D, Viglio, S, Siegmann, N, Iadarola, P, Shute, JK, Geiser, M, Pier, GB, Friedel, G, Barr, ML, Schuster, A, Meyer, KC, Ratjen, F, Bjarnsholt, T, Gulbins, E & Döring, G 2010, 'Alveolar inflammation in cystic fibrosis', Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, vol. 9, no. 3, pp. 217-27. https://doi.org/10.1016/j.jcf.2010.03.001

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abstract = "In infected lungs of the cystic fibrosis (CF) patients, opportunistic pathogens and mutated cystic fibrosis transmembrane conductance regulator protein (CFTR) contribute to chronic airway inflammation that is characterized by neutrophil/macrophage infiltration, cytokine release and ceramide accumulation. We sought to investigate CF lung inflammation in the alveoli.",

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AU - Worlitzsch, Dieter

AU - Viglio, Simona

AU - Siegmann, Nanna

AU - Iadarola, Paolo

AU - Shute, Janis K

AU - Geiser, Marianne

AU - Pier, Gerald B

AU - Friedel, Godehard

AU - Barr, Mark L

AU - Schuster, Antje

AU - Meyer, Keith C

AU - Ratjen, Felix

AU - Bjarnsholt, Thomas

AU - Gulbins, Erich

AU - Döring, Gerd

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AB - In infected lungs of the cystic fibrosis (CF) patients, opportunistic pathogens and mutated cystic fibrosis transmembrane conductance regulator protein (CFTR) contribute to chronic airway inflammation that is characterized by neutrophil/macrophage infiltration, cytokine release and ceramide accumulation. We sought to investigate CF lung inflammation in the alveoli.

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U2 - 10.1016/j.jcf.2010.03.001

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M3 - Journal article

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JO - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

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ER -

Alveolar inflammation in cystic fibrosis

Abstract

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