Alveolar inflammation in cystic fibrosis

Martina Ulrich, Dieter Worlitzsch, Simona Viglio, Nanna Siegmann, Paolo Iadarola, Janis K Shute, Marianne Geiser, Gerald B Pier, Godehard Friedel, Mark L Barr, Antje Schuster, Keith C Meyer, Felix Ratjen, Thomas Bjarnsholt, Erich Gulbins, Gerd Döring

99 Citations (Scopus)

Abstract

In infected lungs of the cystic fibrosis (CF) patients, opportunistic pathogens and mutated cystic fibrosis transmembrane conductance regulator protein (CFTR) contribute to chronic airway inflammation that is characterized by neutrophil/macrophage infiltration, cytokine release and ceramide accumulation. We sought to investigate CF lung inflammation in the alveoli.
Original languageEnglish
JournalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume9
Issue number3
Pages (from-to)217-27
Number of pages11
DOIs
Publication statusPublished - 1 May 2010

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