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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Aluminium contact allergy without vaccination granulomas: A systematic review and meta-analysis

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DOI

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  5. Incidence rates of occupational contact dermatitis in Denmark between 2007 and 2018 - A population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Facial contact dermatitis caused by cosmetic-relevant allergens

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Facial dermatoses in health care professionals induced by the use of protective masks during the COVID-19 pandemic

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Chromium and cobalt release from metallic earrings from the Danish market

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. No immediate effect of regulatory reduction of chromium in leather among adult patients with chromium allergy

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Incidence rates of occupational contact dermatitis in Denmark between 2007 and 2018 - A population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

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Aluminium contact allergy is mainly seen as granulomas following immunization with aluminium-adsorbed vaccines and contact allergy following epicutaneous exposure may be overlooked. To investigate the prevalence of aluminium allergy confirmed by patch testing, with no association with vaccination granulomas, and explore whether epicutaneous exposure to aluminium can contribute to allergic contact dermatitis. Two authors independently searched PubMed and MEDLINE (OVID) for case studies on contact allergy to aluminium proven by patch testing. Age-stratified meta-analyses to calculate the pooled prevalence were performed. Twenty-five studies describing a total of 73 cases were included in the review. Seven studies were suitable for meta-analyses. The prevalence of aluminium contact allergy was 5.61% (95% confidence interval [CI] 0.12%-11.08%) for children and 0.36% (95% CI 0.04%-0.67%) for adults. The studies described a variety of epicutaneous exposures, where metallic aluminium, topical medicaments, and deodorants were the main sources. Aluminium sensitization without a known exposure source was described in 10 of the 25 articles. The prevalence of aluminium contact allergy in the general public may be higher than expected and not solely related to vaccination granulomas. However, the clinical relevance is rare if not related to granulomas.

Original languageEnglish
JournalContact Dermatitis
Volume85
Issue number2
Pages (from-to)129-135
Number of pages7
ISSN0105-1873
DOIs
Publication statusPublished - Aug 2021

    Research areas

  • aluminium, contact allergy, dermatitis, epicutaneous exposure, granuloma, meta-analysis, patch test, prevalence, sensitization, vaccine

ID: 67624715