Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression

24 Citations (Scopus)

Abstract

Healthy first-degree relatives of patients with major depression (rMD+) show brain structure and functional response anomalies and have elevated risk for developing depression, a disorder linked to abnormal serotonergic neurotransmission and reward processing. Method In a two-step functional magnetic resonance imaging (fMRI) investigation, we first evaluated whether positive and negative monetary outcomes were differentially processed by rMD+ individuals compared to healthy first-degree relatives of control probands (rMD-). Second, in a double-blinded placebo-controlled randomized trial we investigated whether a 4-week intervention with the selective serotonergic reuptake inhibitor (SSRI) escitalopram had a normalizing effect on behavior and brain responses of the rMD+ individuals.
Original languageEnglish
JournalPsychological Medicine
Volume44
Issue number6
Pages (from-to)1183-1195
ISSN0033-2917
DOIs
Publication statusPublished - Apr 2014

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