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Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV)

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Harvard

Murray, DD, Zaunders, J, Milliken, ST, Munier, CML, Ford, C, Morrissey, CO, Visweswaran, M, Avery, S, Sasadeusz, J, Kwan, J, Desai, S, Law, M, Koelsch, KK, Lewin, SR, Moore, J, Kelleher, AD & Polizzotto, MN 2021, 'Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV)', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 72, no. 7, pp. 1141-1146. https://doi.org/10.1093/cid/ciaa748

APA

Murray, D. D., Zaunders, J., Milliken, S. T., Munier, C. M. L., Ford, C., Morrissey, C. O., Visweswaran, M., Avery, S., Sasadeusz, J., Kwan, J., Desai, S., Law, M., Koelsch, K. K., Lewin, S. R., Moore, J., Kelleher, A. D., & Polizzotto, M. N. (2021). Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV). Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 72(7), 1141-1146. https://doi.org/10.1093/cid/ciaa748

CBE

Murray DD, Zaunders J, Milliken ST, Munier CML, Ford C, Morrissey CO, Visweswaran M, Avery S, Sasadeusz J, Kwan J, Desai S, Law M, Koelsch KK, Lewin SR, Moore J, Kelleher AD, Polizzotto MN. 2021. Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV). Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 72(7):1141-1146. https://doi.org/10.1093/cid/ciaa748

MLA

Vancouver

Author

Murray, Daniel D ; Zaunders, John ; Milliken, Samuel T ; Munier, C Mee Ling ; Ford, Carole ; Morrissey, C Orla ; Visweswaran, Malini ; Avery, Sharon ; Sasadeusz, Joseph ; Kwan, John ; Desai, Shrinivas ; Law, Matthew ; Koelsch, Kersten K ; Lewin, Sharon R ; Moore, John ; Kelleher, Anthony D ; Polizzotto, Mark N. / Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV). In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 ; Vol. 72, No. 7. pp. 1141-1146.

Bibtex

@article{5ca0f02d927f49deb50e7182d8fa0a85,
title = "Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV)",
abstract = "BACKGROUND: Persons living with human immunodeficiency virus (HIV) are at elevated risk of developing the malignant diseases that require allogeneic stem cell transplantation (ASCT). Recent data suggest that these individuals are also at an elevated risk of certain complications post-ASCT. This risk may result from preexisting HIV-related factors affecting dynamics of immune reconstitution post-ASCT. However, to date, there has been little work describing the dynamics of immune reconstitution post-ASCT in persons with HIV and none comparing these data to controls without HIV.METHODS: We assessed T-cell reconstitution in 6 ASCT with HIV recipients (HIV+ASCT) compared to a control population of 21 ASCT without HIV recipients. In a subset of HIV+ASCT recipients we performed additional flow cytometry profiling of CD8+ T-cell subsets and antigen specificity of reconstituting CD4+ and CD8+ T cells.RESULTS: We observe no difference in post-ASCT CD4+ T cells between HIV+ASCT and HIV-negative ASCT recipients, despite much lower pre-ASCT CD4+ T-cell counts in the HIV+ASCT group. In contrast, we observed significantly higher CD8+ T-cell numbers in the HIV+ASCT group post-ASCT. The reconstituting CD8+ T-cells were predominantly CD45RO+, whereas homing markers and antigen specificity of these cells varied between participants.CONCLUSION: This study represents the most extensive characterization of immune-reconstitution post-ASCT in persons with HIV, and the first to our knowledge to compare these data to ASCT controls without HIV. The results indicate that immune reconstitution in this group can be affected by preexisting HIV infection and post-ASCT antigen exposure.",
keywords = "acute leukemia, allogeneic stem cell transplant, HIV, immune reconstitution, lymphoma",
author = "Murray, {Daniel D} and John Zaunders and Milliken, {Samuel T} and Munier, {C Mee Ling} and Carole Ford and Morrissey, {C Orla} and Malini Visweswaran and Sharon Avery and Joseph Sasadeusz and John Kwan and Shrinivas Desai and Matthew Law and Koelsch, {Kersten K} and Lewin, {Sharon R} and John Moore and Kelleher, {Anthony D} and Polizzotto, {Mark N}",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2021",
month = apr,
day = "8",
doi = "10.1093/cid/ciaa748",
language = "English",
volume = "72",
pages = "1141--1146",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",
number = "7",

}

RIS

TY - JOUR

T1 - Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV)

AU - Murray, Daniel D

AU - Zaunders, John

AU - Milliken, Samuel T

AU - Munier, C Mee Ling

AU - Ford, Carole

AU - Morrissey, C Orla

AU - Visweswaran, Malini

AU - Avery, Sharon

AU - Sasadeusz, Joseph

AU - Kwan, John

AU - Desai, Shrinivas

AU - Law, Matthew

AU - Koelsch, Kersten K

AU - Lewin, Sharon R

AU - Moore, John

AU - Kelleher, Anthony D

AU - Polizzotto, Mark N

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2021/4/8

Y1 - 2021/4/8

N2 - BACKGROUND: Persons living with human immunodeficiency virus (HIV) are at elevated risk of developing the malignant diseases that require allogeneic stem cell transplantation (ASCT). Recent data suggest that these individuals are also at an elevated risk of certain complications post-ASCT. This risk may result from preexisting HIV-related factors affecting dynamics of immune reconstitution post-ASCT. However, to date, there has been little work describing the dynamics of immune reconstitution post-ASCT in persons with HIV and none comparing these data to controls without HIV.METHODS: We assessed T-cell reconstitution in 6 ASCT with HIV recipients (HIV+ASCT) compared to a control population of 21 ASCT without HIV recipients. In a subset of HIV+ASCT recipients we performed additional flow cytometry profiling of CD8+ T-cell subsets and antigen specificity of reconstituting CD4+ and CD8+ T cells.RESULTS: We observe no difference in post-ASCT CD4+ T cells between HIV+ASCT and HIV-negative ASCT recipients, despite much lower pre-ASCT CD4+ T-cell counts in the HIV+ASCT group. In contrast, we observed significantly higher CD8+ T-cell numbers in the HIV+ASCT group post-ASCT. The reconstituting CD8+ T-cells were predominantly CD45RO+, whereas homing markers and antigen specificity of these cells varied between participants.CONCLUSION: This study represents the most extensive characterization of immune-reconstitution post-ASCT in persons with HIV, and the first to our knowledge to compare these data to ASCT controls without HIV. The results indicate that immune reconstitution in this group can be affected by preexisting HIV infection and post-ASCT antigen exposure.

AB - BACKGROUND: Persons living with human immunodeficiency virus (HIV) are at elevated risk of developing the malignant diseases that require allogeneic stem cell transplantation (ASCT). Recent data suggest that these individuals are also at an elevated risk of certain complications post-ASCT. This risk may result from preexisting HIV-related factors affecting dynamics of immune reconstitution post-ASCT. However, to date, there has been little work describing the dynamics of immune reconstitution post-ASCT in persons with HIV and none comparing these data to controls without HIV.METHODS: We assessed T-cell reconstitution in 6 ASCT with HIV recipients (HIV+ASCT) compared to a control population of 21 ASCT without HIV recipients. In a subset of HIV+ASCT recipients we performed additional flow cytometry profiling of CD8+ T-cell subsets and antigen specificity of reconstituting CD4+ and CD8+ T cells.RESULTS: We observe no difference in post-ASCT CD4+ T cells between HIV+ASCT and HIV-negative ASCT recipients, despite much lower pre-ASCT CD4+ T-cell counts in the HIV+ASCT group. In contrast, we observed significantly higher CD8+ T-cell numbers in the HIV+ASCT group post-ASCT. The reconstituting CD8+ T-cells were predominantly CD45RO+, whereas homing markers and antigen specificity of these cells varied between participants.CONCLUSION: This study represents the most extensive characterization of immune-reconstitution post-ASCT in persons with HIV, and the first to our knowledge to compare these data to ASCT controls without HIV. The results indicate that immune reconstitution in this group can be affected by preexisting HIV infection and post-ASCT antigen exposure.

KW - acute leukemia

KW - allogeneic stem cell transplant

KW - HIV

KW - immune reconstitution

KW - lymphoma

UR - http://www.scopus.com/inward/record.url?scp=85104160291&partnerID=8YFLogxK

U2 - 10.1093/cid/ciaa748

DO - 10.1093/cid/ciaa748

M3 - Journal article

C2 - 32520987

VL - 72

SP - 1141

EP - 1146

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 7

ER -

ID: 60546178