TY - JOUR
T1 - Altered body composition in male long-term survivors of paediatric allogeneic haematopoietic stem cell transplantation
T2 - impact of conditioning regimen, chronic graft-versus-host disease and hypogonadism
AU - Mejdahl Nielsen, Malene
AU - Mathiesen, Sidsel
AU - Suominen, Anu
AU - Sørensen, Kaspar
AU - Ifversen, Marianne
AU - Mølgaard, Christian
AU - Lähteenmäki, Päivi M
AU - Juul, Anders
AU - Jahnukainen, Kirsi
AU - Müller, Klaus
PY - 2021/2
Y1 - 2021/2
N2 - Changes in body composition related to metabolic syndrome are frequent among survivors of haematopoietic stem cell transplantation (HSCT), but insights into predisposing factors are incomplete, and it is unknown to what degree these changes persist at long term. We cross-sectionally investigated body composition by dual-energy X-ray absorptiometry in 98 male survivors of paediatric allogeneic HSCT. Median (range) age at follow-up was 28.1 (18.5-47.0) years and median (range) time from transplant was 18.3 (7.7-34.6) years. Lean Body Mass Index and Skeletal Muscle Mass Index were lower in patients compared to the reference population (mean (SD) standard deviation score (SDS) -1.29 (0.99), p < 0.001 and -1.20 (1.03), p < 0.001). Fat Mass Index was comparable to the reference population, but android/gynoid (AG) fat ratio SDS was higher (mean (SD) 0.46 (1.28), p < 0.001). These changes were found in patients treated with total body irradiation (TBI) as well as non-TBI regimens, although most pronounced in the former. Further, low lean mass was associated with chronic graft-versus-host disease, while high AG ratio was associated with lower testosterone levels. Since the combination of low lean mass and high AG ratio increases the risk of cardio-metabolic disease, these health issues should be monitored at long-term clinical follow-up after paediatric HSCT.
AB - Changes in body composition related to metabolic syndrome are frequent among survivors of haematopoietic stem cell transplantation (HSCT), but insights into predisposing factors are incomplete, and it is unknown to what degree these changes persist at long term. We cross-sectionally investigated body composition by dual-energy X-ray absorptiometry in 98 male survivors of paediatric allogeneic HSCT. Median (range) age at follow-up was 28.1 (18.5-47.0) years and median (range) time from transplant was 18.3 (7.7-34.6) years. Lean Body Mass Index and Skeletal Muscle Mass Index were lower in patients compared to the reference population (mean (SD) standard deviation score (SDS) -1.29 (0.99), p < 0.001 and -1.20 (1.03), p < 0.001). Fat Mass Index was comparable to the reference population, but android/gynoid (AG) fat ratio SDS was higher (mean (SD) 0.46 (1.28), p < 0.001). These changes were found in patients treated with total body irradiation (TBI) as well as non-TBI regimens, although most pronounced in the former. Further, low lean mass was associated with chronic graft-versus-host disease, while high AG ratio was associated with lower testosterone levels. Since the combination of low lean mass and high AG ratio increases the risk of cardio-metabolic disease, these health issues should be monitored at long-term clinical follow-up after paediatric HSCT.
UR - http://www.scopus.com/inward/record.url?scp=85090139036&partnerID=8YFLogxK
U2 - 10.1038/s41409-020-01038-3
DO - 10.1038/s41409-020-01038-3
M3 - Journal article
C2 - 32879430
SN - 0268-3369
VL - 56
SP - 457
EP - 460
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 2
ER -