Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Assessment of Suicide Risks During the First Week Immediately After Discharge From Psychiatric Inpatient Facility

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Corrigendum: Relationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Disturbances of Shared Intentionality in Schizophrenia and Autism

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. An observational study of emotion regulation in children with Tourette syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Educational attainment does not influence brain aging

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Does pericentral mu-rhythm "power" corticomotor excitability? - a matter of EEG perspective

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Children, adolescents, and young adults with at least one first-degree relative [familial high-risk (FHR)] with either schizophrenia (SZ) or bipolar disorder (BD) have a one-in-two risk of developing a psychiatric disorder. Here, we review functional magnetic resonance imaging (fMRI) studies which examined task-related brain activity in young individuals with FHR-SZ and FHR-BD. A systematic search identified all published task-related fMRI studies in children, adolescents, and young adults below an age of 27 years with a first-degree relative with SZ or BD, but without manifest psychotic or affective spectrum disorder themselves. The search identified 19 cross-sectional fMRI studies covering four main cognitive domains: 1) working memory (n = 3), 2) cognitive control (n = 4), 3) reward processing (n = 3), and 4) emotion processing (n = 9). Thirteen studies included FHR-BD, five studies included FHR-SZ, and one study included a pooled FHR group. In general, task performance did not differ between the respective FHR groups and healthy controls, but 18 out of the 19 fMRI studies revealed regional alterations in task-related activation. Brain regions showing group differences in peak activation were regions associated with the respective task domain and showed little overlap between FHR-SZ and FHR-BD. The low number of studies, together with the low number of subjects, and the substantial heterogeneity of employed methodological approaches within the domain of working memory, cognitive control, and reward processing impedes finite conclusions. Emotion processing was the most investigated task domain in FHR-BD. Four studies reported differences in activation of the amygdala, and two studies reported differences in activation of inferior frontal/middle gyrus. Together, these studies provide evidence for altered brain processing of emotions in children, adolescents, and young adults at FHR-BD. More studies of higher homogeneity, larger sample sizes and with a longitudinal study design are warranted to prove a shared or specific FHR-related endophenotypic brain activation in young first-degree relatives of individuals with SZ or BD, as well as to pinpoint specific alterations in brain activation during cognitive-, emotional-, and reward-related tasks.

Original languageEnglish
Article number632
JournalFrontiers in Psychiatry
Volume11
Pages (from-to)1-16
Number of pages16
ISSN1664-0640
DOIs
Publication statusPublished - 10 Jul 2020

ID: 60589357