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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655

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Multiple sclerosis (MS) is a complex autoimmune disease affecting genetically susceptible individuals. A genome-wide association study performed by the International MS Genetics Consortium identified several putative susceptibility genes; among these, the KLRB1 gene is represented by the single-nucleotide polymorphism rs4763655. We could confirm a marginally significant association between rs4763655 and MS (P=0.046, odds ratio=1.06 (1.00-1.13)) in a large Scandinavian case-control study of 5367 MS patients and 4485 controls. The expression of KLRB1 in blood from MS patients was higher compared with healthy controls (P
Original languageEnglish
JournalEuropean Journal of Human Genetics
Volume19
Issue number10
Pages (from-to)1100-3
Number of pages4
ISSN1018-4813
DOIs
Publication statusPublished - 2011

ID: 33166819