Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Alteplase (rtPA) treatment of intraventricular hematoma (IVH): safety of an efficient methodological approach for rapid clot removal

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Living with the cerebellar mutism syndrome: long-term challenges of the diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Automated pupillometry and the FOUR score - what is the diagnostic benefit in neurointensive care?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Tumor miRNA expression profile is related to vestibular schwannoma growth rate

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Laser Ablation of Abnormal Neurological Tissue Using Robotic Neuroblate System (LAANTERN): Procedural Safety and Hospitalization

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Clinical and histopathological predictors of outcome in malignant meningioma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Organisering af Perifer Nervekirurgi i Danmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Adaptive hybrid surgery analysis (AHSA) for adjuvant gamma knife radiosurgery treatment of vestibular schwannoma residuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Delayed cerebral ischaemia in patients with aneurysmal subarachnoid haemorrhage: Functional outcome and long-term mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Intraventricular hemorrhage (IVH) subsequent to intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH) is associated with high mortality and morbidity. The use of fibrinolytic agents to treat this condition has previously been reported in small clinical trials with limited numbers of patients. Variability regarding inclusion criteria, method of administration and outcome have made it difficult to draw firm conclusions regarding the efficacy of antifibrinolytic therapy. Nine patients with CT-diagnosed IVH were treated with Alteplase intrathecally for 3 to 5 days according to the CT-verified clearance of IVH. After the treatment period, a repeat CT scan was performed to evaluate treatment effect.In this safety study, we achieved rapid removal of IVH compared to retrospective controls, without incidents of re-bleeding, with only 33% permanent shunt placements and a neurological outcome of GOS of 4-5 in 44% of the patients. Based on the above results, the treatment protocol was considered safe and highly effective. A prospective randomized national multicenter trial has been initiated in order to evaluate the efficacy of this novel method also in terms of outcome and shunt dependency.
Original languageEnglish
JournalActa Neurochirurgica
Volume111
Pages (from-to)409-13
Number of pages5
ISSN0001-6268
DOIs
Publication statusPublished - 2011

    Research areas

  • Adult, Aged, Cerebral Hemorrhage, Female, Fibrinolytic Agents, Glasgow Coma Scale, Hematoma, Humans, Male, Middle Aged, Severity of Illness Index, Subarachnoid Hemorrhage, Suction, Tissue Plasminogen Activator, Tomography, X-Ray Computed, Treatment Outcome

ID: 33273901