Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation

Arnon Nagler; Vanderson Rocha; Myriam Labopin; Ali Unal; Tarek Ben Othman; Antonio Campos; Liisa Volin; Xavier Poire; Mahmoud Aljurf; Tamás Masszi; Gerard Socie; Henrik Sengelov; Mauricette Michallet; Jakob Passweg; Hendrik Veelken; Ibrahim Yakoub-Agha; Avichai Shimoni; Mohamad Mohty

doi:10.1200/JCO.2013.48.8114

Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation

Arnon Nagler, Vanderson Rocha, Myriam Labopin, Ali Unal, Tarek Ben Othman, Antonio Campos, Liisa Volin, Xavier Poire, Mahmoud Aljurf, Tamás Masszi, Gerard Socie, Henrik Sengelov, Mauricette Michallet, Jakob Passweg, Hendrik Veelken, Ibrahim Yakoub-Agha, Avichai Shimoni, Mohamad Mohty

147 Citations (Scopus)

Abstract

Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a safer toxicity profile than the oral formulation. Comparative studies of outcomes have been performed between oral Bu/Cy and Cy/TBI, but there have been no comparative trials in the era of IV Bu.

Original language	English
Journal	Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume	31
Issue number	28
Pages (from-to)	3549-56
Number of pages	8
ISSN	0732-183X
DOIs	https://doi.org/10.1200/JCO.2013.48.8114
Publication status	Published - 1 Oct 2013

Keywords

Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Busulfan
Chemoradiotherapy
Cyclophosphamide
Female
Follow-Up Studies
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Injections, Intravenous
Leukemia, Myeloid, Acute
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Remission Induction
Retrospective Studies
Survival Rate
Transplantation Conditioning
Transplantation, Homologous
Whole-Body Irradiation
Young Adult

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Nagler, A., Rocha, V., Labopin, M., Unal, A., Ben Othman, T., Campos, A., Volin, L., Poire, X., Aljurf, M., Masszi, T., Socie, G., Sengelov, H., Michallet, M., Passweg, J., Veelken, H., Yakoub-Agha, I., Shimoni, A., & Mohty, M. (2013). Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(28), 3549-56. https://doi.org/10.1200/JCO.2013.48.8114

Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation. / Nagler, Arnon; Rocha, Vanderson; Labopin, Myriam et al.
In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 31, No. 28, 01.10.2013, p. 3549-56.

Research output: Contribution to journal › Journal article › Research › peer-review

Nagler, A, Rocha, V, Labopin, M, Unal, A, Ben Othman, T, Campos, A, Volin, L, Poire, X, Aljurf, M, Masszi, T, Socie, G, Sengelov, H, Michallet, M, Passweg, J, Veelken, H, Yakoub-Agha, I, Shimoni, A & Mohty, M 2013, 'Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation', Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 31, no. 28, pp. 3549-56. https://doi.org/10.1200/JCO.2013.48.8114

Nagler A, Rocha V, Labopin M, Unal A, Ben Othman T, Campos A et al. Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2013 Oct 1;31(28):3549-56. doi: 10.1200/JCO.2013.48.8114

Nagler, Arnon ; Rocha, Vanderson ; Labopin, Myriam et al. / Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission : comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation. In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2013 ; Vol. 31, No. 28. pp. 3549-56.

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abstract = "Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a safer toxicity profile than the oral formulation. Comparative studies of outcomes have been performed between oral Bu/Cy and Cy/TBI, but there have been no comparative trials in the era of IV Bu.",

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AU - Nagler, Arnon

AU - Rocha, Vanderson

AU - Labopin, Myriam

AU - Unal, Ali

AU - Ben Othman, Tarek

AU - Campos, Antonio

AU - Volin, Liisa

AU - Poire, Xavier

AU - Aljurf, Mahmoud

AU - Masszi, Tamás

AU - Socie, Gerard

AU - Sengelov, Henrik

AU - Michallet, Mauricette

AU - Passweg, Jakob

AU - Veelken, Hendrik

AU - Yakoub-Agha, Ibrahim

AU - Shimoni, Avichai

AU - Mohty, Mohamad

PY - 2013/10/1

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N2 - Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a safer toxicity profile than the oral formulation. Comparative studies of outcomes have been performed between oral Bu/Cy and Cy/TBI, but there have been no comparative trials in the era of IV Bu.

AB - Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a safer toxicity profile than the oral formulation. Comparative studies of outcomes have been performed between oral Bu/Cy and Cy/TBI, but there have been no comparative trials in the era of IV Bu.

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KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

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KW - Remission Induction

KW - Retrospective Studies

KW - Survival Rate

KW - Transplantation Conditioning

KW - Transplantation, Homologous

KW - Whole-Body Irradiation

KW - Young Adult

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M3 - Journal article

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SN - 0732-183X

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JO - Journal of clinical oncology : official journal of the American Society of Clinical Oncology

JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology

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Abstract

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