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Allergic contact dermatitis caused by hydroperoxides of limonene and dose-response relationship-A repeated open application test (ROAT) study

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BACKGROUND: Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim-OOHs) as the main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions have been reported.

OBJECTIVES: To determine the clinical relevance, elicitation threshold and dose-response relationship of Lim-OOHs in individuals with a positive or doubtful patch test reaction to standard Lim-OOHs 0.3% pet.

METHODS: A multicentre 3-week double-blind vehicle-controlled repeated open application test (ROAT) study with a simulated fine fragrance containing Lim-OOHs at 1260, 420 and 140 ppm, equal to a dose/area per application of Lim-OOHs of 3.0, 0.99 and 0.33 μg/cm2 , was performed.

RESULTS: Among 11 subjects allergic to Lim-OOHs, 11 (100%), 7 (64%), and 3 (27%), respectively, reacted to the applied doses. No reactions were seen in 17 healthy controls exposed to the highest dose. This difference in reactivity was statistically significant (P < 0.0001). Among 13 subjects with doubtful patch test reactions to Lim-OOHs, two (15%) had positive ROAT reactions to the highest Lim-OOH dose applied (P = 0.36 as compared with controls).

CONCLUSIONS: Contact allergy to Lim-OOHs is of clinical relevance in patients with positive patch test reactions. A doubtful patch test reaction to Lim-OOHs 0.3% pet. can be of clinical relevance.

Original languageEnglish
JournalContact Dermatitis
Volume80
Issue number4
Pages (from-to)208-216
Number of pages9
ISSN0105-1873
DOIs
Publication statusPublished - Apr 2019

    Research areas

  • Adult, Allergens/administration & dosage, Dermatitis, Allergic Contact/diagnosis, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Hydrogen Peroxide/administration & dosage, Male, Middle Aged, Monoterpenes/administration & dosage, Patch Tests, Perfume/administration & dosage, allergic contact dermatitis, clinical relevance, contact allergy, ROAT, fragrance substance, dose-response relationship, limonene hydroperoxides, oxidized limonene

ID: 57655921