Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

José L Santos; Rolando De la Cruz; Claus Holst; Katrine Grau; Carolina Naranjo; Alberto Maiz; Arne Astrup; Wim H M Saris; Ian MacDonald; Jean-Michel Oppert; Torben Hansen; Oluf Pedersen; Thorkild I A Sorensen; J Alfredo Martinez; NUGENOB Consortium

doi:10.1371/journal.pone.0019934

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

José L Santos, Rolando De la Cruz, Claus Holst, Katrine Grau, Carolina Naranjo, Alberto Maiz, Arne Astrup, Wim H M Saris, Ian MacDonald, Jean-Michel Oppert, Torben Hansen, Oluf Pedersen, Thorkild I A Sorensen, J Alfredo Martinez, NUGENOB Consortium

24 Citations (Scopus)

Abstract

The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets.

Original language	English
Journal	P L o S One
Volume	6
Issue number	6
Pages (from-to)	e19934
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0019934
Publication status	Published - 2011

Keywords

Adipose Tissue
Adult
Alleles
Animals
Diet, Fat-Restricted
Diet, Reducing
Dietary Fats
Energy Metabolism
Female
Genotype
Humans
Linkage Disequilibrium
Male
Mice
Middle Aged
Obesity
Polymorphism, Single Nucleotide
Receptor, Melanocortin, Type 3
Waist Circumference
Weight Loss
Young Adult

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Santos, J. L., De la Cruz, R., Holst, C., Grau, K., Naranjo, C., Maiz, A., Astrup, A., Saris, W. H. M., MacDonald, I., Oppert, J.-M., Hansen, T., Pedersen, O., Sorensen, T. I. A., Martinez, J. A., & NUGENOB Consortium (2011). Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. P L o S One, 6(6), e19934. https://doi.org/10.1371/journal.pone.0019934

Santos, JL, De la Cruz, R, Holst, C, Grau, K, Naranjo, C, Maiz, A, Astrup, A, Saris, WHM, MacDonald, I, Oppert, J-M, Hansen, T, Pedersen, O, Sorensen, TIA, Martinez, JA & NUGENOB Consortium 2011, 'Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets', P L o S One, vol. 6, no. 6, pp. e19934. https://doi.org/10.1371/journal.pone.0019934

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title = "Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets",

abstract = "The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets.",

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AU - Naranjo, Carolina

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AU - Saris, Wim H M

AU - MacDonald, Ian

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AB - The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets.

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KW - Diet, Fat-Restricted

KW - Diet, Reducing

KW - Dietary Fats

KW - Energy Metabolism

KW - Female

KW - Genotype

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Mice

KW - Middle Aged

KW - Obesity

KW - Polymorphism, Single Nucleotide

KW - Receptor, Melanocortin, Type 3

KW - Waist Circumference

KW - Weight Loss

KW - Young Adult

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SP - e19934

JO - P L o S One

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IS - 6

ER -

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

Abstract

Keywords

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