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Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

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@article{793653d1a9a549af9c80eca107a47036,
title = "Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort",
abstract = "BACKGROUND AND OBJECTIVE: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.METHODS: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.RESULTS: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women ( p < 0.001) and men ( p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95{\%} confidence interval (CI): 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95{\%} CI: 0.38-0.62) and high consumption (OR = 0.57, 95{\%} CI: 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95{\%} CI: 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.CONCLUSION: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.",
keywords = "Adolescence, alcohol, epidemiology, multiple sclerosis",
author = "Christina Andersen and S{\o}ndergaard, {Helle Bach} and {Bang Oturai}, Ditte and Laursen, {Julie Hejgaard} and Stefan Gustavsen and Larsen, {Nanna Katrine} and Melinda Magyari and Emilie Just-{\O}stergaard and Th{\o}rner, {Lise Wegner} and Finn Sellebjerg and Henrik Ullum and Oturai, {Annette Bang}",
year = "2019",
month = "10",
doi = "10.1177/1352458518795418",
language = "English",
volume = "25",
pages = "1572--1579",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "Sage Science Press (UK)",
number = "12",

}

RIS

TY - JOUR

T1 - Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

AU - Andersen, Christina

AU - Søndergaard, Helle Bach

AU - Bang Oturai, Ditte

AU - Laursen, Julie Hejgaard

AU - Gustavsen, Stefan

AU - Larsen, Nanna Katrine

AU - Magyari, Melinda

AU - Just-Østergaard, Emilie

AU - Thørner, Lise Wegner

AU - Sellebjerg, Finn

AU - Ullum, Henrik

AU - Oturai, Annette Bang

PY - 2019/10

Y1 - 2019/10

N2 - BACKGROUND AND OBJECTIVE: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.METHODS: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.RESULTS: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women ( p < 0.001) and men ( p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38-0.62) and high consumption (OR = 0.57, 95% CI: 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.CONCLUSION: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

AB - BACKGROUND AND OBJECTIVE: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.METHODS: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.RESULTS: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women ( p < 0.001) and men ( p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38-0.62) and high consumption (OR = 0.57, 95% CI: 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.CONCLUSION: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

KW - Adolescence

KW - alcohol

KW - epidemiology

KW - multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=85052570049&partnerID=8YFLogxK

U2 - 10.1177/1352458518795418

DO - 10.1177/1352458518795418

M3 - Journal article

VL - 25

SP - 1572

EP - 1579

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 12

ER -

ID: 55401760