Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

Christina Andersen; Helle Bach Søndergaard; Ditte Bang Oturai; Julie Hejgaard Laursen; Stefan Gustavsen; Nanna Katrine Larsen; Melinda Magyari; Emilie Just-Østergaard; Lise Wegner Thørner; Finn Sellebjerg; Henrik Ullum; Annette Bang Oturai

doi:10.1177/1352458518795418

Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

Christina Andersen, Helle Bach Søndergaard, Ditte Bang Oturai, Julie Hejgaard Laursen, Stefan Gustavsen, Nanna Katrine Larsen, Melinda Magyari, Emilie Just-Østergaard, Lise Wegner Thørner, Finn Sellebjerg, Henrik Ullum, Annette Bang Oturai

21 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.

METHODS: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.

RESULTS: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women ( p < 0.001) and men ( p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38-0.62) and high consumption (OR = 0.57, 95% CI: 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.

CONCLUSION: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

Original language	English
Journal	Multiple sclerosis
Volume	25
Issue number	12
Pages (from-to)	1572-1579
ISSN	1352-4585
DOIs	https://doi.org/10.1177/1352458518795418
Publication status	Published - Oct 2019

Keywords

Adolescence
alcohol
epidemiology
multiple sclerosis

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10.1177/1352458518795418

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Andersen, C., Søndergaard, H. B., Bang Oturai, D., Laursen, J. H., Gustavsen, S., Larsen, N. K., Magyari, M., Just-Østergaard, E., Thørner, L. W., Sellebjerg, F., Ullum, H., & Oturai, A. B. (2019). Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort. Multiple sclerosis, 25(12), 1572-1579. https://doi.org/10.1177/1352458518795418

Andersen, C, Søndergaard, HB, Bang Oturai, D, Laursen, JH, Gustavsen, S, Larsen, NK, Magyari, M, Just-Østergaard, E, Thørner, LW, Sellebjerg, F, Ullum, H & Oturai, AB 2019, 'Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort', Multiple sclerosis, vol. 25, no. 12, pp. 1572-1579. https://doi.org/10.1177/1352458518795418

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title = "Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort",

abstract = "BACKGROUND AND OBJECTIVE: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.METHODS: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.RESULTS: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women ( p < 0.001) and men ( p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95\% confidence interval (CI): 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95\% CI: 0.38-0.62) and high consumption (OR = 0.57, 95\% CI: 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95\% CI: 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.CONCLUSION: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.",

keywords = "Adolescence, alcohol, epidemiology, multiple sclerosis",

author = "Christina Andersen and S{\o}ndergaard, \{Helle Bach\} and \{Bang Oturai\}, Ditte and Laursen, \{Julie Hejgaard\} and Stefan Gustavsen and Larsen, \{Nanna Katrine\} and Melinda Magyari and Emilie Just-{\O}stergaard and Th{\o}rner, \{Lise Wegner\} and Finn Sellebjerg and Henrik Ullum and Oturai, \{Annette Bang\}",

year = "2019",

month = oct,

doi = "10.1177/1352458518795418",

language = "English",

volume = "25",

pages = "1572--1579",

journal = "Multiple sclerosis",

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T1 - Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

AU - Andersen, Christina

AU - Søndergaard, Helle Bach

AU - Bang Oturai, Ditte

AU - Laursen, Julie Hejgaard

AU - Gustavsen, Stefan

AU - Larsen, Nanna Katrine

AU - Magyari, Melinda

AU - Just-Østergaard, Emilie

AU - Thørner, Lise Wegner

AU - Sellebjerg, Finn

AU - Ullum, Henrik

AU - Oturai, Annette Bang

PY - 2019/10

Y1 - 2019/10

N2 - BACKGROUND AND OBJECTIVE: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.METHODS: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.RESULTS: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women ( p < 0.001) and men ( p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38-0.62) and high consumption (OR = 0.57, 95% CI: 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.CONCLUSION: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

AB - BACKGROUND AND OBJECTIVE: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.METHODS: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.RESULTS: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women ( p < 0.001) and men ( p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38-0.62) and high consumption (OR = 0.57, 95% CI: 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.CONCLUSION: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

KW - Adolescence

KW - alcohol

KW - epidemiology

KW - multiple sclerosis

UR - https://www.scopus.com/pages/publications/85052570049

U2 - 10.1177/1352458518795418

DO - 10.1177/1352458518795418

M3 - Journal article

C2 - 30124094

SN - 1352-4585

VL - 25

SP - 1572

EP - 1579

JO - Multiple sclerosis

JF - Multiple sclerosis

IS - 12

ER -

Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

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