Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The quality of dietary carbohydrate and fat is associated with better metabolic control in persons with type 1 and type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Adolescent wine consumption is inversely associated with long-term weight gain: results from follow-up of 20 or 22 years

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Population-based studies of relationships between dietary acidity load, insulin resistance and incident diabetes in Danes

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. TVT or TVT-O? - A systematic review and meta-analysis comparing efficacy, complications and re-operations

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

BACKGROUND: Studies have suggested a link between alcohol intake and adiposity. However, results from longitudinal studies have been inconsistent, and a possible interaction with genetic predisposition to adiposity measures has often not been taken into account.

OBJECTIVE: To examine the association between alcohol intake recorded at baseline and subsequent annual changes in body weight (∆BW), waist circumference (ΔWC) and WC adjusted for BMI (ΔWCBMI), and to test for interaction with genetic predisposition scores based on single nucleotide polymorphisms (SNPs) associated with various forms of adiposity.

METHOD: This study included a total of 7028 adult men and women from MONICA, the Diet, Cancer and Health cohort (DCH), and the Inter99 studies. We combined 50 adiposity-associated SNPs into four scores indicating genetic predisposition to BMI, WC, WHRBMI and all three traits combined. Linear regression was used to examine the association of alcohol intake (drinks of 12 g (g) alcohol/day) with ΔBW, ΔWC, and ΔWCBMI, and to examine possible interactions with SNP-scores. Results from the analyses of the individual cohorts were combined in meta-analyses.

RESULTS: Each additional drink/day was associated with a ΔBW/year of -18.0 g (95% confidence interval (CI): -33.4, -2.6, P = 0.02) and a ΔWC of -0.3 mm/year (-0.5, -0.0, P = 0.03). In analyses of women only, alcohol intake was associated with a higher ΔWCBMI of 0.5 mm/year (0.2, 0.9, P = 0.002) per drink/day. Overall, we found no statistically significant interactions between the four SNP-scores and alcohol intake in relation to changes in adiposity measures. However in analyses of women separately, we found interaction between the complete score of all 50 SNPs and alcohol intake in relation to ΔBW (P for interaction = 0.03). No significant interaction was observed among the men.

CONCLUSION: Alcohol intake was associated with a decrease in BW and WC among men and women, and an increase in WCBMI among women only. We found no strong indication that these associations depend on a genetic predisposition to adiposity.

TRIAL REGISTRATION: Registry: ClinicalTrials.gov Trial number: CT00289237 , Registered: 19 September 2005 retrospectively registered.

Original languageEnglish
JournalNutrition Journal
Volume16
Issue number1
Pages (from-to)51
ISSN1475-2891
DOIs
Publication statusPublished - 25 Aug 2017

    Research areas

  • Journal Article

ID: 51690594