Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials

Frank A Holtkamp; Dick de Zeeuw; Pieter A de Graeff; Gozewijn D Laverman; Tom Berl; Giuseppe Remuzzi; David Packham; Julia B Lewis; Hans-Henrik Parving; Hiddo J Lambers Heerspink

doi:10.1093/eurheartj/ehr017

Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials

Frank A Holtkamp, Dick de Zeeuw, Pieter A de Graeff, Gozewijn D Laverman, Tom Berl, Giuseppe Remuzzi, David Packham, Julia B Lewis, Hans-Henrik Parving, Hiddo J Lambers Heerspink

116 Citations (Scopus)

Abstract

The long-term cardioprotective effect of angiotensin receptor blockers (ARBs) is associated with the short-term lowering of its primary target blood pressure, but also with the lowering of albuminuria. Since the individual blood pressure and albuminuria response to an ARB varies between and within an individual, we tested whether the variability and discordance in systolic blood pressure (SBP) and albuminuria response to ARB therapy are associated with its long-term effect on cardiovascular outcomes.

Original language	English
Journal	European Heart Journal (English Edition)
Volume	32
Issue number	12
Pages (from-to)	1493-9
Number of pages	7
ISSN	0195-668X
DOIs	https://doi.org/10.1093/eurheartj/ehr017
Publication status	Published - 2011

Keywords

Aged
Albuminuria
Amlodipine
Angiotensin Receptor Antagonists
Biphenyl Compounds
Blood Pressure
Calcium Channel Blockers
Cardiotonic Agents
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Diabetic Nephropathies
Female
Heart Failure
Humans
Hypertension
Losartan
Male
Middle Aged
Myocardial Infarction
Randomized Controlled Trials as Topic
Retrospective Studies
Risk Factors
Stroke
Tetrazoles
Treatment Outcome

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10.1093/eurheartj/ehr017

Cite this

Holtkamp, F. A., de Zeeuw, D., de Graeff, P. A., Laverman, G. D., Berl, T., Remuzzi, G., Packham, D., Lewis, J. B., Parving, H.-H., & Lambers Heerspink, H. J. (2011). Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials. European Heart Journal (English Edition), 32(12), 1493-9. https://doi.org/10.1093/eurheartj/ehr017

Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials. / Holtkamp, Frank A; de Zeeuw, Dick; de Graeff, Pieter A et al.
In: European Heart Journal (English Edition), Vol. 32, No. 12, 2011, p. 1493-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Holtkamp, FA, de Zeeuw, D, de Graeff, PA, Laverman, GD, Berl, T, Remuzzi, G, Packham, D, Lewis, JB, Parving, H-H & Lambers Heerspink, HJ 2011, 'Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials', European Heart Journal (English Edition), vol. 32, no. 12, pp. 1493-9. https://doi.org/10.1093/eurheartj/ehr017

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abstract = "The long-term cardioprotective effect of angiotensin receptor blockers (ARBs) is associated with the short-term lowering of its primary target blood pressure, but also with the lowering of albuminuria. Since the individual blood pressure and albuminuria response to an ARB varies between and within an individual, we tested whether the variability and discordance in systolic blood pressure (SBP) and albuminuria response to ARB therapy are associated with its long-term effect on cardiovascular outcomes.",

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Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials

Abstract

Keywords

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