Air pollution, oxidative damage to DNA, and carcinogenesis

Peter Møller; Janne Kjaersgaard Folkmann; Lykke Forchhammer; Elvira Vaclavik Bräuner; Pernille Høgh Danielsen; Lotte Risom; Steffen Loft

doi:10.1016/j.canlet.2008.02.030

Air pollution, oxidative damage to DNA, and carcinogenesis

Peter Møller, Janne Kjaersgaard Folkmann, Lykke Forchhammer, Elvira Vaclavik Bräuner, Pernille Høgh Danielsen, Lotte Risom, Steffen Loft

218 Citations (Scopus)

Abstract

There is growing concern that air pollution exposure increases the risk of lung cancer. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Humans exposed to urban air with vehicle emissions have elevated levels of oxidized guanine bases in blood cells and urine. Animal experimental studies show that pulmonary and gastrointestinal exposure is associated with elevated levels of oxidized guanines in the lung and other organs. Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.

Original language	English
Journal	Cancer Letters
Volume	266
Issue number	1
Pages (from-to)	84-97
Number of pages	14
ISSN	0304-3835
DOIs	https://doi.org/10.1016/j.canlet.2008.02.030
Publication status	Published - 18 Jul 2008
Externally published	Yes

Keywords

Air Pollution/adverse effects
Animals
Carcinogens/toxicity
Cell Transformation, Neoplastic
DNA Damage
Guinea Pigs
Humans
Mice
Neoplasms/chemically induced
Oxidation-Reduction
Oxidative Stress
Particulate Matter/toxicity
Rats
Vehicle Emissions/toxicity

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10.1016/j.canlet.2008.02.030

Cite this

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title = "Air pollution, oxidative damage to DNA, and carcinogenesis",

abstract = "There is growing concern that air pollution exposure increases the risk of lung cancer. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Humans exposed to urban air with vehicle emissions have elevated levels of oxidized guanine bases in blood cells and urine. Animal experimental studies show that pulmonary and gastrointestinal exposure is associated with elevated levels of oxidized guanines in the lung and other organs. Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.",

keywords = "Air Pollution/adverse effects, Animals, Carcinogens/toxicity, Cell Transformation, Neoplastic, DNA Damage, Guinea Pigs, Humans, Mice, Neoplasms/chemically induced, Oxidation-Reduction, Oxidative Stress, Particulate Matter/toxicity, Rats, Vehicle Emissions/toxicity",

author = "Peter M{\o}ller and Folkmann, \{Janne Kjaersgaard\} and Lykke Forchhammer and Br{\"a}uner, \{Elvira Vaclavik\} and Danielsen, \{Pernille H{\o}gh\} and Lotte Risom and Steffen Loft",

year = "2008",

month = jul,

day = "18",

doi = "10.1016/j.canlet.2008.02.030",

language = "English",

volume = "266",

pages = "84--97",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - Air pollution, oxidative damage to DNA, and carcinogenesis

AU - Møller, Peter

AU - Folkmann, Janne Kjaersgaard

AU - Forchhammer, Lykke

AU - Bräuner, Elvira Vaclavik

AU - Danielsen, Pernille Høgh

AU - Risom, Lotte

AU - Loft, Steffen

PY - 2008/7/18

Y1 - 2008/7/18

N2 - There is growing concern that air pollution exposure increases the risk of lung cancer. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Humans exposed to urban air with vehicle emissions have elevated levels of oxidized guanine bases in blood cells and urine. Animal experimental studies show that pulmonary and gastrointestinal exposure is associated with elevated levels of oxidized guanines in the lung and other organs. Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.

AB - There is growing concern that air pollution exposure increases the risk of lung cancer. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Humans exposed to urban air with vehicle emissions have elevated levels of oxidized guanine bases in blood cells and urine. Animal experimental studies show that pulmonary and gastrointestinal exposure is associated with elevated levels of oxidized guanines in the lung and other organs. Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.

KW - Air Pollution/adverse effects

KW - Animals

KW - Carcinogens/toxicity

KW - Cell Transformation, Neoplastic

KW - DNA Damage

KW - Guinea Pigs

KW - Humans

KW - Mice

KW - Neoplasms/chemically induced

KW - Oxidation-Reduction

KW - Oxidative Stress

KW - Particulate Matter/toxicity

KW - Rats

KW - Vehicle Emissions/toxicity

UR - https://www.scopus.com/pages/publications/44449089858

U2 - 10.1016/j.canlet.2008.02.030

DO - 10.1016/j.canlet.2008.02.030

M3 - Review

C2 - 18367322

SN - 0304-3835

VL - 266

SP - 84

EP - 97

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Air pollution, oxidative damage to DNA, and carcinogenesis

Abstract

Keywords

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