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Aggressive multiple sclerosis (2): Treatment

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  1. The introduction of new medications in pediatric multiple sclerosis: Open issues and challenges

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  2. Exposure to passive smoking during adolescence is associated with an increased risk of developing multiple sclerosis

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  3. COVID-19 in people with multiple sclerosis: A global data sharing initiative

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  1. Dimethyl Fumarate Treatment in Patients With Primary Progressive Multiple Sclerosis: A Randomized, Controlled Trial

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  2. Neurovascular contact plays no role in trigeminal neuralgia secondary to multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The introduction of new medications in pediatric multiple sclerosis: Open issues and challenges

    Research output: Contribution to journalJournal articleResearchpeer-review

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The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.

Original languageEnglish
JournalMultiple Sclerosis Journal
Volume26
Issue number9
Pages (from-to)1045-1063
ISSN1352-4585
DOIs
Publication statusPublished - 12 Jun 2020

    Research areas

  • Aggressive, highly active, multiple sclerosis, disability, relapsing-remitting, treatment response

ID: 61515402