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Ageing as a risk factor for neurodegenerative disease

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Harvard

Hou, Y, Dan, X, Babbar, M, Wei, Y, Hasselbalch, SG, Croteau, DL & Bohr, VA 2019, 'Ageing as a risk factor for neurodegenerative disease' Nature reviews. Neurology, vol. 15, no. 10, pp. 565-581. https://doi.org/10.1038/s41582-019-0244-7

APA

Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A. (2019). Ageing as a risk factor for neurodegenerative disease. Nature reviews. Neurology, 15(10), 565-581. https://doi.org/10.1038/s41582-019-0244-7

CBE

MLA

Vancouver

Author

Hou, Yujun ; Dan, Xiuli ; Babbar, Mansi ; Wei, Yong ; Hasselbalch, Steen G ; Croteau, Deborah L ; Bohr, Vilhelm A. / Ageing as a risk factor for neurodegenerative disease. In: Nature reviews. Neurology. 2019 ; Vol. 15, No. 10. pp. 565-581.

Bibtex

@article{2880c259940949cd9560efe683f3b029,
title = "Ageing as a risk factor for neurodegenerative disease",
abstract = "Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). One in ten individuals aged ≥65 years has AD and its prevalence continues to increase with increasing age. Few or no effective treatments are available for ageing-related neurodegenerative diseases, which tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs. This Review discusses the pathogenesis of AD, PD and other neurodegenerative diseases, and describes their associations with the nine biological hallmarks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion and altered intercellular communication. The central biological mechanisms of ageing and their potential as targets of novel therapies for neurodegenerative diseases are also discussed, with potential therapies including NAD+ precursors, mitophagy inducers and inhibitors of cellular senescence.",
author = "Yujun Hou and Xiuli Dan and Mansi Babbar and Yong Wei and Hasselbalch, {Steen G} and Croteau, {Deborah L} and Bohr, {Vilhelm A}",
year = "2019",
month = "10",
doi = "10.1038/s41582-019-0244-7",
language = "English",
volume = "15",
pages = "565--581",
journal = "Nature Reviews Neurology",
issn = "1759-4758",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - Ageing as a risk factor for neurodegenerative disease

AU - Hou, Yujun

AU - Dan, Xiuli

AU - Babbar, Mansi

AU - Wei, Yong

AU - Hasselbalch, Steen G

AU - Croteau, Deborah L

AU - Bohr, Vilhelm A

PY - 2019/10

Y1 - 2019/10

N2 - Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). One in ten individuals aged ≥65 years has AD and its prevalence continues to increase with increasing age. Few or no effective treatments are available for ageing-related neurodegenerative diseases, which tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs. This Review discusses the pathogenesis of AD, PD and other neurodegenerative diseases, and describes their associations with the nine biological hallmarks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion and altered intercellular communication. The central biological mechanisms of ageing and their potential as targets of novel therapies for neurodegenerative diseases are also discussed, with potential therapies including NAD+ precursors, mitophagy inducers and inhibitors of cellular senescence.

AB - Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). One in ten individuals aged ≥65 years has AD and its prevalence continues to increase with increasing age. Few or no effective treatments are available for ageing-related neurodegenerative diseases, which tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs. This Review discusses the pathogenesis of AD, PD and other neurodegenerative diseases, and describes their associations with the nine biological hallmarks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion and altered intercellular communication. The central biological mechanisms of ageing and their potential as targets of novel therapies for neurodegenerative diseases are also discussed, with potential therapies including NAD+ precursors, mitophagy inducers and inhibitors of cellular senescence.

U2 - 10.1038/s41582-019-0244-7

DO - 10.1038/s41582-019-0244-7

M3 - Review

VL - 15

SP - 565

EP - 581

JO - Nature Reviews Neurology

JF - Nature Reviews Neurology

SN - 1759-4758

IS - 10

ER -

ID: 58035588