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Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan

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@article{69e93ba6721740b19217bc05eaf44359,
title = "Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan",
abstract = "BACKGROUND: Our main goal was to evaluate the pattern and time course of changes in relative muscle power and its constituting components throughout the life span.METHODS: A total of 1,305 subjects (729 women and 576 men; aged 20-93 years) participating in the Copenhagen Sarcopenia Study took part. Body mass index (BMI), leg lean mass assessed by dual-energy X-ray absorptiometry (DXA), and leg extension muscle power (LEP) assessed by the Nottingham power rig were recorded. Relative muscle power (normalized to body mass) and specific muscle power (normalized to leg lean mass) were calculated. Segmented regression analyses were used to identify the onset and pattern of age-related changes in the recorded variables.RESULTS: Relative muscle power began to decline above the age of 40 in both women and men, with women showing an attenuation of the decline above 75 years. Relative muscle power decreased with age due to (i) the loss of absolute LEP after the fourth decade of life and (ii) the increase in BMI up to the age of 75 years in women and 65 years in men. The decline in absolute LEP was caused by a decline in specific LEP up to the age of 75 in women and 65 in men, above which the loss in relative leg lean mass also contributed.CONCLUSIONS: Relative power decreased (i) above 40 years by the loss in absolute power (specific power only) and the increase in body mass, and (ii) above ~70 years by the loss in absolute power (both specific power and leg lean mass).",
keywords = "Aging, Body mass index, Dynapenia, Leg extension power, Sarcopenia, Skeletal muscle",
author = "Julian Alcazar and Per Aagaard and Bryan Haddock and Kamper, {Rikke S} and Hansen, {Sofie K} and Eva Prescott and Alegre, {Luis M} and Ulrik Frandsen and Charlotte Suetta",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2020",
month = jul,
doi = "10.1093/gerona/glaa013",
language = "English",
volume = "75",
pages = "1369--1378",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan

AU - Alcazar, Julian

AU - Aagaard, Per

AU - Haddock, Bryan

AU - Kamper, Rikke S

AU - Hansen, Sofie K

AU - Prescott, Eva

AU - Alegre, Luis M

AU - Frandsen, Ulrik

AU - Suetta, Charlotte

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: Our main goal was to evaluate the pattern and time course of changes in relative muscle power and its constituting components throughout the life span.METHODS: A total of 1,305 subjects (729 women and 576 men; aged 20-93 years) participating in the Copenhagen Sarcopenia Study took part. Body mass index (BMI), leg lean mass assessed by dual-energy X-ray absorptiometry (DXA), and leg extension muscle power (LEP) assessed by the Nottingham power rig were recorded. Relative muscle power (normalized to body mass) and specific muscle power (normalized to leg lean mass) were calculated. Segmented regression analyses were used to identify the onset and pattern of age-related changes in the recorded variables.RESULTS: Relative muscle power began to decline above the age of 40 in both women and men, with women showing an attenuation of the decline above 75 years. Relative muscle power decreased with age due to (i) the loss of absolute LEP after the fourth decade of life and (ii) the increase in BMI up to the age of 75 years in women and 65 years in men. The decline in absolute LEP was caused by a decline in specific LEP up to the age of 75 in women and 65 in men, above which the loss in relative leg lean mass also contributed.CONCLUSIONS: Relative power decreased (i) above 40 years by the loss in absolute power (specific power only) and the increase in body mass, and (ii) above ~70 years by the loss in absolute power (both specific power and leg lean mass).

AB - BACKGROUND: Our main goal was to evaluate the pattern and time course of changes in relative muscle power and its constituting components throughout the life span.METHODS: A total of 1,305 subjects (729 women and 576 men; aged 20-93 years) participating in the Copenhagen Sarcopenia Study took part. Body mass index (BMI), leg lean mass assessed by dual-energy X-ray absorptiometry (DXA), and leg extension muscle power (LEP) assessed by the Nottingham power rig were recorded. Relative muscle power (normalized to body mass) and specific muscle power (normalized to leg lean mass) were calculated. Segmented regression analyses were used to identify the onset and pattern of age-related changes in the recorded variables.RESULTS: Relative muscle power began to decline above the age of 40 in both women and men, with women showing an attenuation of the decline above 75 years. Relative muscle power decreased with age due to (i) the loss of absolute LEP after the fourth decade of life and (ii) the increase in BMI up to the age of 75 years in women and 65 years in men. The decline in absolute LEP was caused by a decline in specific LEP up to the age of 75 in women and 65 in men, above which the loss in relative leg lean mass also contributed.CONCLUSIONS: Relative power decreased (i) above 40 years by the loss in absolute power (specific power only) and the increase in body mass, and (ii) above ~70 years by the loss in absolute power (both specific power and leg lean mass).

KW - Aging

KW - Body mass index

KW - Dynapenia

KW - Leg extension power

KW - Sarcopenia

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=85086746582&partnerID=8YFLogxK

U2 - 10.1093/gerona/glaa013

DO - 10.1093/gerona/glaa013

M3 - Journal article

C2 - 31943003

VL - 75

SP - 1369

EP - 1378

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 7

ER -

ID: 61664909