Adverse effects of biologics: a network meta-analysis and Cochrane overview

Jasvinder A Singh; George A Wells; Robin Christensen; Elizabeth Tanjong Ghogomu; Lara Maxwell; John K Macdonald; Graziella Filippini; Nicole Skoetz; Damian Francis; Luciane C Lopes; Gordon H Guyatt; Jochen Schmitt; Loredana La Mantia; Tobias Weberschock; Juliana F Roos; Hendrik Siebert; Sarah Hershan; Michael Pt Lunn; Peter Tugwell; Rachelle Buchbinder

doi:10.1002/14651858.CD008794.pub2

Adverse effects of biologics: a network meta-analysis and Cochrane overview

Jasvinder A Singh, George A Wells, Robin Christensen, Elizabeth Tanjong Ghogomu, Lara Maxwell, John K Macdonald, Graziella Filippini, Nicole Skoetz, Damian Francis, Luciane C Lopes, Gordon H Guyatt, Jochen Schmitt, Loredana La Mantia, Tobias Weberschock, Juliana F Roos, Hendrik Siebert, Sarah Hershan, Michael Pt Lunn, Peter Tugwell, Rachelle Buchbinder

The Parker Institute

864 Citations (Scopus)

Abstract

Biologics are used for the treatment of rheumatoid arthritis and many other conditions. While the efficacy of biologics has been established, there is uncertainty regarding the adverse effects of this treatment. Since serious risks such as tuberculosis (TB) reactivation, serious infections, and lymphomas may be common to the biologics but occur in small numbers across the various indications, we planned to combine the results from biologics used in many conditions to obtain the much needed risk estimates.

Original language	English
Journal	Cochrane Database of Systematic Reviews
Issue number	2
Pages (from-to)	CD008794
ISSN	1469-493X
DOIs	https://doi.org/10.1002/14651858.CD008794.pub2
Publication status	Published - 1 Jan 2011

Keywords

Antibodies, Monoclonal
Biological Products
Humans
Immunologic Factors
Patient Dropouts
Randomized Controlled Trials as Topic

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Singh, J. A., Wells, G. A., Christensen, R., Tanjong Ghogomu, E., Maxwell, L., Macdonald, J. K., Filippini, G., Skoetz, N., Francis, D., Lopes, L. C., Guyatt, G. H., Schmitt, J., La Mantia, L., Weberschock, T., Roos, J. F., Siebert, H., Hershan, S., Lunn, M. P., Tugwell, P., & Buchbinder, R. (2011). Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database of Systematic Reviews, (2), CD008794. https://doi.org/10.1002/14651858.CD008794.pub2

Singh, JA, Wells, GA, Christensen, R, Tanjong Ghogomu, E, Maxwell, L, Macdonald, JK, Filippini, G, Skoetz, N, Francis, D, Lopes, LC, Guyatt, GH, Schmitt, J, La Mantia, L, Weberschock, T, Roos, JF, Siebert, H, Hershan, S, Lunn, MP, Tugwell, P & Buchbinder, R 2011, 'Adverse effects of biologics: a network meta-analysis and Cochrane overview', Cochrane Database of Systematic Reviews, no. 2, pp. CD008794. https://doi.org/10.1002/14651858.CD008794.pub2

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AU - Macdonald, John K

AU - Filippini, Graziella

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AU - Francis, Damian

AU - Lopes, Luciane C

AU - Guyatt, Gordon H

AU - Schmitt, Jochen

AU - La Mantia, Loredana

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AU - Roos, Juliana F

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KW - Biological Products

KW - Humans

KW - Immunologic Factors

KW - Patient Dropouts

KW - Randomized Controlled Trials as Topic

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Adverse effects of biologics: a network meta-analysis and Cochrane overview

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Keywords

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