Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia

Research output: Contribution to journalReviewpeer-review

  1. Antiplatelets after intracerebral haemorrhage: treat the patient, not the brain imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 3rd edition, 2020

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Dependence-like behaviour in patients treated for medication overuse headache: A prospective open-label randomized controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Comparison of 3 Treatment Strategies for Medication Overuse Headache: A Randomized Clinical Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. REFERENCEPROGRAM: Diagnostik og behandling af hovedpinesygdomme og ansigtssmerter

    Research output: Book/ReportReportCommunication

View graph of relations

Trigeminal neuralgia is a very painful neurological condition with severe, stimulus-evoked, short-lasting stabbing pain attacks in the face. The past decade has offered new insights into trigeminal neuralgia symptomatology, pathophysiology, and treatment, leading to a change in the classification of the condition. An accurate diagnosis is crucial because neuroimaging interpretation and clinical management differ among the various forms of facial pain. MRI using specific sequences should be a part of the diagnostic workup to detect a possible neurovascular contact and exclude secondary causes. Demonstration of a neurovascular contact should not be used to confirm a diagnosis but rather to facilitate surgical decision making. Carbamazepine and oxcarbazepine are drugs of first choice for long-term treatment, whereas microvascular decompression is the first-line surgery in medically refractory patients. Advances in neuroimaging techniques and animal models will provide further insight into the causes of trigeminal neuralgia and its pathophysiology. Development of more efficacious treatment options is highly warranted.

Original languageEnglish
JournalThe Lancet Neurology
Volume19
Issue number9
Pages (from-to)784-796
Number of pages13
ISSN1474-4422
DOIs
Publication statusPublished - 2020

    Research areas

  • Animals, Anticonvulsants/pharmacology, Carbamazepine/pharmacology, Decompression, Surgical/methods, Disease Management, Humans, Neuroimaging/methods, Oxcarbazepine/pharmacology, Pain Measurement/drug effects, Trigeminal Neuralgia/classification

ID: 60922701