Advanced quantitative echocardiography in arrhythmogenic right ventricular cardiomyopathy

Jesper Kjaergaard; Jesper Hastrup Svendsen; Peter Sogaard; Xu Chen; Henning Bay Nielsen; Lars Køber; Andreas Kjaer; Christian Hassager

doi:10.1016/j.echo.2006.07.006

Advanced quantitative echocardiography in arrhythmogenic right ventricular cardiomyopathy

Jesper Kjaergaard, Jesper Hastrup Svendsen, Peter Sogaard, Xu Chen, Henning Bay Nielsen, Lars Køber, Andreas Kjaer, Christian Hassager

Department of Clinical Physiology and Nuclear Medicine

51 Citations (Scopus)

Abstract

BACKGROUND: Arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) is a regional disease of the RV myocardium with variable degrees of left ventricular involvement. Three-dimensional echocardiography and Doppler tissue imaging (DTI) are new echocardiographic modalities for the evaluation of global and regional function, but the diagnostic potential remains to be assessed.

METHODS: Twenty patients with previously established ARVC were evaluated by 3-dimensional echocardiography and DTI, and compared with 32 age- and sex-matched control subjects.

RESULTS: Using 3-dimensional echocardiography, patients with ARVC had a decreased RV ejection fraction (0.47 +/- 0.08 vs 0.53 +/- 0.05, P < .01), and a decreased peak lateral systolic annular velocity by pulsed wave imaging of both the RV (11.9 +/- 2.6 vs 15.1 +/- 3.7 cm/s, P < .01) and the left ventricle (7.0 +/- 2.6 vs 9.5 +/- 1.9 cm/s, P < .01). DTI showed decreased regional systolic strain, but with wide variation in the measurements.

CONCLUSION: Three-dimensional echocardiography identifies decreased RV ejection fraction in ARVC. Assessment of regional contractility by DTI is limited by wide variation. Echocardiographic evaluation of the longitudinal motility appears to be a sensitive marker of preclinical left ventricular involvement.

Original language	English
Journal	Journal of the American Society of Echocardiography
Volume	20
Issue number	1
Pages (from-to)	27-35
Number of pages	9
ISSN	0894-7317
DOIs	https://doi.org/10.1016/j.echo.2006.07.006
Publication status	Published - Jan 2007

Keywords

Adult
Aged
Arrhythmogenic Right Ventricular Dysplasia
Atrial Natriuretic Factor
Biomarkers
Biopsy, Needle
Case-Control Studies
Confidence Intervals
Echocardiography
Echocardiography, Three-Dimensional
Female
Heart Function Tests
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Natriuretic Peptide, Brain
Probability
Reference Values
Sensitivity and Specificity
Severity of Illness Index
Ventricular Dysfunction, Right
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.echo.2006.07.006

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title = "Advanced quantitative echocardiography in arrhythmogenic right ventricular cardiomyopathy",

abstract = "BACKGROUND: Arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) is a regional disease of the RV myocardium with variable degrees of left ventricular involvement. Three-dimensional echocardiography and Doppler tissue imaging (DTI) are new echocardiographic modalities for the evaluation of global and regional function, but the diagnostic potential remains to be assessed.METHODS: Twenty patients with previously established ARVC were evaluated by 3-dimensional echocardiography and DTI, and compared with 32 age- and sex-matched control subjects.RESULTS: Using 3-dimensional echocardiography, patients with ARVC had a decreased RV ejection fraction (0.47 +/- 0.08 vs 0.53 +/- 0.05, P < .01), and a decreased peak lateral systolic annular velocity by pulsed wave imaging of both the RV (11.9 +/- 2.6 vs 15.1 +/- 3.7 cm/s, P < .01) and the left ventricle (7.0 +/- 2.6 vs 9.5 +/- 1.9 cm/s, P < .01). DTI showed decreased regional systolic strain, but with wide variation in the measurements.CONCLUSION: Three-dimensional echocardiography identifies decreased RV ejection fraction in ARVC. Assessment of regional contractility by DTI is limited by wide variation. Echocardiographic evaluation of the longitudinal motility appears to be a sensitive marker of preclinical left ventricular involvement.",

keywords = "Adult, Aged, Arrhythmogenic Right Ventricular Dysplasia, Atrial Natriuretic Factor, Biomarkers, Biopsy, Needle, Case-Control Studies, Confidence Intervals, Echocardiography, Echocardiography, Three-Dimensional, Female, Heart Function Tests, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Natriuretic Peptide, Brain, Probability, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Ventricular Dysfunction, Right, Journal Article, Research Support, Non-U.S. Gov't",

author = "Jesper Kjaergaard and \{Hastrup Svendsen\}, Jesper and Peter Sogaard and Xu Chen and \{Bay Nielsen\}, Henning and Lars K{\o}ber and Andreas Kjaer and Christian Hassager",

year = "2007",

month = jan,

doi = "10.1016/j.echo.2006.07.006",

language = "English",

volume = "20",

pages = "27--35",

journal = "Journal of the American Society of Echocardiography",

issn = "0894-7317",

publisher = "Elsevier Inc.",

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T1 - Advanced quantitative echocardiography in arrhythmogenic right ventricular cardiomyopathy

AU - Kjaergaard, Jesper

AU - Hastrup Svendsen, Jesper

AU - Sogaard, Peter

AU - Chen, Xu

AU - Bay Nielsen, Henning

AU - Køber, Lars

AU - Kjaer, Andreas

AU - Hassager, Christian

PY - 2007/1

Y1 - 2007/1

N2 - BACKGROUND: Arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) is a regional disease of the RV myocardium with variable degrees of left ventricular involvement. Three-dimensional echocardiography and Doppler tissue imaging (DTI) are new echocardiographic modalities for the evaluation of global and regional function, but the diagnostic potential remains to be assessed.METHODS: Twenty patients with previously established ARVC were evaluated by 3-dimensional echocardiography and DTI, and compared with 32 age- and sex-matched control subjects.RESULTS: Using 3-dimensional echocardiography, patients with ARVC had a decreased RV ejection fraction (0.47 +/- 0.08 vs 0.53 +/- 0.05, P < .01), and a decreased peak lateral systolic annular velocity by pulsed wave imaging of both the RV (11.9 +/- 2.6 vs 15.1 +/- 3.7 cm/s, P < .01) and the left ventricle (7.0 +/- 2.6 vs 9.5 +/- 1.9 cm/s, P < .01). DTI showed decreased regional systolic strain, but with wide variation in the measurements.CONCLUSION: Three-dimensional echocardiography identifies decreased RV ejection fraction in ARVC. Assessment of regional contractility by DTI is limited by wide variation. Echocardiographic evaluation of the longitudinal motility appears to be a sensitive marker of preclinical left ventricular involvement.

AB - BACKGROUND: Arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) is a regional disease of the RV myocardium with variable degrees of left ventricular involvement. Three-dimensional echocardiography and Doppler tissue imaging (DTI) are new echocardiographic modalities for the evaluation of global and regional function, but the diagnostic potential remains to be assessed.METHODS: Twenty patients with previously established ARVC were evaluated by 3-dimensional echocardiography and DTI, and compared with 32 age- and sex-matched control subjects.RESULTS: Using 3-dimensional echocardiography, patients with ARVC had a decreased RV ejection fraction (0.47 +/- 0.08 vs 0.53 +/- 0.05, P < .01), and a decreased peak lateral systolic annular velocity by pulsed wave imaging of both the RV (11.9 +/- 2.6 vs 15.1 +/- 3.7 cm/s, P < .01) and the left ventricle (7.0 +/- 2.6 vs 9.5 +/- 1.9 cm/s, P < .01). DTI showed decreased regional systolic strain, but with wide variation in the measurements.CONCLUSION: Three-dimensional echocardiography identifies decreased RV ejection fraction in ARVC. Assessment of regional contractility by DTI is limited by wide variation. Echocardiographic evaluation of the longitudinal motility appears to be a sensitive marker of preclinical left ventricular involvement.

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KW - Aged

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KW - Biomarkers

KW - Biopsy, Needle

KW - Case-Control Studies

KW - Confidence Intervals

KW - Echocardiography

KW - Echocardiography, Three-Dimensional

KW - Female

KW - Heart Function Tests

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain

KW - Probability

KW - Reference Values

KW - Sensitivity and Specificity

KW - Severity of Illness Index

KW - Ventricular Dysfunction, Right

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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M3 - Journal article

C2 - 17218199

SN - 0894-7317

VL - 20

SP - 27

EP - 35

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

IS - 1

ER -

Advanced quantitative echocardiography in arrhythmogenic right ventricular cardiomyopathy

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