Adult Immunohistochemical Markers Fail to Detect Intratubular Germ Cell Neoplasia in Prepubertal Boys with Cryptorchidism

Kolja Kvist; Erik Clasen-Linde; Dina Cortes; Bodil Laub Petersen; Jorgen Thorup

doi:10.1016/j.juro.2013.10.001

Adult Immunohistochemical Markers Fail to Detect Intratubular Germ Cell Neoplasia in Prepubertal Boys with Cryptorchidism

Kolja Kvist, Erik Clasen-Linde, Dina Cortes, Bodil Laub Petersen, Jorgen Thorup

18 Citations (Scopus)

Abstract

Intratubular germ cell neoplasia is a precursor to testicular germ cell cancer. The condition is characterized by large germ cells with large nuclei with a hyperchromatic, coarse chromatin pattern, large prominent nucleoli and abundant pale cytoplasm. In prepubertal boys these cells are located centrally and peripherally mixed with normal cells in the seminiferous tubules. We evaluated the impact of adult intratubular germ cell neoplasia marking immunohistochemistry in screening for intratubular germ cell neoplasia in boys with cryptorchidism.

Original language	English
Journal	The Journal of urology
Volume	191
Issue number	4
Pages (from-to)	e1084-9
ISSN	0022-5347
DOIs	https://doi.org/10.1016/j.juro.2013.10.001
Publication status	Published - 3 Oct 2014

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10.1016/j.juro.2013.10.001

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title = "Adult Immunohistochemical Markers Fail to Detect Intratubular Germ Cell Neoplasia in Prepubertal Boys with Cryptorchidism",

abstract = "Intratubular germ cell neoplasia is a precursor to testicular germ cell cancer. The condition is characterized by large germ cells with large nuclei with a hyperchromatic, coarse chromatin pattern, large prominent nucleoli and abundant pale cytoplasm. In prepubertal boys these cells are located centrally and peripherally mixed with normal cells in the seminiferous tubules. We evaluated the impact of adult intratubular germ cell neoplasia marking immunohistochemistry in screening for intratubular germ cell neoplasia in boys with cryptorchidism.",

author = "Kolja Kvist and Erik Clasen-Linde and Dina Cortes and Petersen, \{Bodil Laub\} and Jorgen Thorup",

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AU - Kvist, Kolja

AU - Clasen-Linde, Erik

AU - Cortes, Dina

AU - Petersen, Bodil Laub

AU - Thorup, Jorgen

PY - 2014/10/3

Y1 - 2014/10/3

N2 - Intratubular germ cell neoplasia is a precursor to testicular germ cell cancer. The condition is characterized by large germ cells with large nuclei with a hyperchromatic, coarse chromatin pattern, large prominent nucleoli and abundant pale cytoplasm. In prepubertal boys these cells are located centrally and peripherally mixed with normal cells in the seminiferous tubules. We evaluated the impact of adult intratubular germ cell neoplasia marking immunohistochemistry in screening for intratubular germ cell neoplasia in boys with cryptorchidism.

AB - Intratubular germ cell neoplasia is a precursor to testicular germ cell cancer. The condition is characterized by large germ cells with large nuclei with a hyperchromatic, coarse chromatin pattern, large prominent nucleoli and abundant pale cytoplasm. In prepubertal boys these cells are located centrally and peripherally mixed with normal cells in the seminiferous tubules. We evaluated the impact of adult intratubular germ cell neoplasia marking immunohistochemistry in screening for intratubular germ cell neoplasia in boys with cryptorchidism.

UR - https://www.scopus.com/pages/publications/84898483617

U2 - 10.1016/j.juro.2013.10.001

DO - 10.1016/j.juro.2013.10.001

M3 - Journal article

C2 - 24095908

SN - 0022-5347

VL - 191

SP - e1084-9

JO - The Journal of urology

JF - The Journal of urology

IS - 4

ER -

Adult Immunohistochemical Markers Fail to Detect Intratubular Germ Cell Neoplasia in Prepubertal Boys with Cryptorchidism

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