Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group

A F Attanasio; S W Lamberts; A M Matranga; M A Birkett; P C Bates; N K Valk; J Hilsted; Birgit Bengtsson; C J Strasburger

Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group

A F Attanasio, S W Lamberts, A M Matranga, M A Birkett, P C Bates, N K Valk, J Hilsted, Birgit Bengtsson, C J Strasburger

Hospital Management and Administration Rigshospitalet

395 Citations (Scopus)

Abstract

The onset of adult GH deficiency may be during either adulthood (AO) or childhood (CO), but potential differences have not previously been examined. In this study the baseline and GH therapy (12.5 micrograms/kg per day) data from CO (n = 74; mean age 29 yr) and AO (n = 99; mean age 44 yr) GH-deficient adult patients have been compared. The first 6 months comprised randomized, double-blind treatment with GH or placebo, then all patients were GH-treated for a further 12 months. At baseline the height, body weight, body mass index, lean body mass, and waist/hip ratio of AO patients were significantly (P

Original language	English
Journal	The Journal of clinical endocrinology and metabolism
Volume	82
Issue number	1
Pages (from-to)	82-8
Number of pages	7
ISSN	0021-972X
Publication status	Published - Jan 1997

Keywords

Adult
Aging
Body Composition
Body Constitution
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Double-Blind Method
Female
Human Growth Hormone
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Male
Middle Aged
Placebos
Skinfold Thickness

Cite this

Attanasio, A. F., Lamberts, S. W., Matranga, A. M., Birkett, M. A., Bates, P. C., Valk, N. K., Hilsted, J., Bengtsson, B., & Strasburger, C. J. (1997). Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group. The Journal of clinical endocrinology and metabolism, 82(1), 82-8.

Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group. / Attanasio, A F; Lamberts, S W; Matranga, A M et al.
In: The Journal of clinical endocrinology and metabolism, Vol. 82, No. 1, 01.1997, p. 82-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Attanasio, AF, Lamberts, SW, Matranga, AM, Birkett, MA, Bates, PC, Valk, NK, Hilsted, J, Bengtsson, B & Strasburger, CJ 1997, 'Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group', The Journal of clinical endocrinology and metabolism, vol. 82, no. 1, pp. 82-8.

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abstract = "The onset of adult GH deficiency may be during either adulthood (AO) or childhood (CO), but potential differences have not previously been examined. In this study the baseline and GH therapy (12.5 micrograms/kg per day) data from CO (n = 74; mean age 29 yr) and AO (n = 99; mean age 44 yr) GH-deficient adult patients have been compared. The first 6 months comprised randomized, double-blind treatment with GH or placebo, then all patients were GH-treated for a further 12 months. At baseline the height, body weight, body mass index, lean body mass, and waist/hip ratio of AO patients were significantly (P ",

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AU - Matranga, A M

AU - Birkett, M A

AU - Bates, P C

AU - Valk, N K

AU - Hilsted, J

AU - Bengtsson, Birgit

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AB - The onset of adult GH deficiency may be during either adulthood (AO) or childhood (CO), but potential differences have not previously been examined. In this study the baseline and GH therapy (12.5 micrograms/kg per day) data from CO (n = 74; mean age 29 yr) and AO (n = 99; mean age 44 yr) GH-deficient adult patients have been compared. The first 6 months comprised randomized, double-blind treatment with GH or placebo, then all patients were GH-treated for a further 12 months. At baseline the height, body weight, body mass index, lean body mass, and waist/hip ratio of AO patients were significantly (P

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KW - Aging

KW - Body Composition

KW - Body Constitution

KW - Cholesterol

KW - Cholesterol, HDL

KW - Cholesterol, LDL

KW - Double-Blind Method

KW - Female

KW - Human Growth Hormone

KW - Humans

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KW - Insulin-Like Growth Factor I

KW - Male

KW - Middle Aged

KW - Placebos

KW - Skinfold Thickness

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Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group

Abstract

Keywords

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