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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Adult Growth Hormone Deficiency: from Transition to Senescence

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  1. Alpha-mannosidosis - a review of genetic, clinical findings and options of treatment

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  2. Clinical care of adult Turner syndrome--new aspects

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  3. Surgical treatment and follow up on undescended testis

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  4. The role of growth hormone in the pathogenesis of diabetic kidney disease

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  1. Characterisation and localisation of the endocannabinoid system components in the adult human testis

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  2. Possible link between FSH and RANKL release from adipocytes in men with impaired gonadal function including Klinefelter syndrome

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  3. Characterization of Human Adrenal Steroidogenesis during Fetal Development

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  4. Populations, decreasing fertility, and reproductive health

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  5. Why do normal children have acromegalic levels of IGF-I during puberty?

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  • Jens Ol Jørgensen
  • Kasper Hermansen
  • Kirstine Stochholm
  • Anders Juul
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The acute metabolic actions of hGH were discovered in GH-deficient adults (GHDA) 60 years ago and placebo controlled trials of prolonged rhGH replacement therapy appeared 30 years after. Untreated GHDA causes excess morbidity and mortality from cardiovascular disease and the clinical features include fatigue, reduced aerobic exercise capacity, abdominal obesity, reduced lean body mass, osteopenia, and elevated levels of circulating cardiovascular risk biomarkers. Several of these abnormalities normalize with GH replacement. Frequent side effects are fluid retention and insulin resistance, which are reversible and dose-dependent. The dose requirement declines with age and is higher in women. Continuation of GH replacement into adulthood is indicated in some patients with childhood-onset disease so the diagnosis must be reassessed. Observational data show that mortality in GH replaced patients is reduced compared to untreated patients. Thus, GH replacement in GHDA has proven beneficial and safe.

Original languageEnglish
JournalPediatric Endocrinology Reviews
Volume16
Issue numberSuppl 1
Pages (from-to)70-79
Number of pages10
ISSN1565-4753
DOIs
Publication statusPublished - Sep 2018

ID: 55611487