Adoptive cell transfer in the treatment of metastatic melanoma

Per thor Straten, Jürgen C Becker

Abstract

Adoptive cell therapy (ACT) for metastatic cancer is the focus of considerable research effort. Rosenberg's laboratory demonstrated a 50% response rate in stage IV melanoma patients treated with in vitro expanded tumor-infiltrating lymphocytes (TILs) and high-dose IL-2 administered after nonmyeloablative conditioning (Dudley et al., 2002a). Because early attempts to use expanded TILs in melanoma therapy failed to demonstrate better efficacy than high-dose IL-2 (Rosenberg et al., 1994), the efficacy of TILs and nonmyeloablative conditioning in combination implies that patient conditioning is crucial to clinical success. The 2002 data represent a milestone in cellular cancer therapy and a turning point for ACT in cancer treatment.

Original languageEnglish
JournalThe Journal of investigative dermatology
Volume129
Issue number12
Pages (from-to)2743-5
Number of pages3
ISSN0022-202X
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Adoptive Transfer
  • Humans
  • Melanoma/immunology
  • Skin Neoplasms/immunology

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