Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Admission Leukocyte Count is Associated with Late Cardiogenic Shock Development and All-Cause 30-Day Mortality in Patients with St-Elevation Myocardial Infarction

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Acute Lung Injury in Critically Ill Patients: Actin-Scavenger Gelsolin Signals Prolonged Respiratory Failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lactate is a Prognostic Factor in Patients Admitted with Suspected ST-Elevation Myocardial Infarction

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Absences of Endothelial Microvesicle Changes in the Presence of the Endotheliopathy of Trauma

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump for Cardiogenic Shock

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ultrasound-assisted thrombolysis for acute intermediate-high-risk pulmonary embolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Age-specific trends in incidence and survival of out-of-hospital cardiac arrest from presumed cardiac cause in Denmark 2002-2014

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Thirty-day mortality in ST-elevation myocardial infarction (STEMI) patients is primarily driven by cardiogenic shock (CS). High neutrophil counts and high neutrophil/lymphocyte ratios (NLR) have previously been associated with mortality in STEMI patients, however, there is only sparse knowledge regarding their association with CS.

PURPOSE: We sought to assess the associations between neutrophil count and NLR with the development of CS as well as 30-day mortality in STEMI patients.

METHODS: Patients admitted with STEMI at two tertiary Heart Centres throughout one year were included in the study and stratified into quartiles according to the level of leukocyte count upon admission. The primary endpoint was development of CS both before (early CS) and after leaving the catheterization laboratory (late CS). The secondary endpoint was all-cause 30-day mortality.

RESULTS: A total of 1892 STEMI patients were included, whereof 194 (10%) developed CS while 122 (6.4%) died within 30 days. Patients in the highest quartile of neutrophils (OR:2.54; 95%CI: 1.40-4.60; p = 0.002) and NLR (OR:3.64; 95%CI: 2.02-6.54; p<0.0001) were at increased risk of developing late CS compared to patients in the lower quartiles, whereas there was no risk difference across quartiles regarding development of early CS. Both biomarkers correlated strongly to an increased 30-day mortality (plogrank<0.0001) and, moreover, a high level of neutrophils was independently associated with 30-day mortality (HR:1.95; 95%CI: 1.25-3.03; p = 0.003).

CONCLUSION: High levels of neutrophils and a high NLR upon admission for STEMI were independently associated with an increased risk of developing late CS and, additionally, both biomarkers showed association to 30-day mortality.

Original languageEnglish
JournalShock
Volume53
Issue number3
Pages (from-to)299-306
ISSN1073-2322
DOIs
Publication statusPublished - Mar 2020

ID: 57662783