Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-term exposure to air pollution and stroke incidence: A Danish Nurse cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Long-term wind turbine noise exposure and the risk of incident atrial fibrillation in the Danish Nurse cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Long-term wind turbine noise exposure and incidence of myocardial infarction in the Danish nurse cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Predicting Transdermal Uptake of Phthalates and a Paraben from Cosmetic Cream Using the Measured Fugacity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. BPA and risk assessment

    Research output: Contribution to journalLetterResearchpeer-review

  • F Artacho-Cordón
  • S Ríos-Arrabal
  • J León
  • H Frederiksen
  • J M Sáenz
  • P Martín-Olmedo
  • M F Fernández
  • N Olea
  • J P Arrebola
View graph of relations

The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative microenvironment in adipose tissue. This study was conducted in a subsample (n = 144) of the GraMo cohort (Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted for potential confounders. Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx) activity [exp(β) = 1.20, p = 0.060] and decreased levels of reduced glutathione (GSH) [exp(β) = 0.55, p = 0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione reductase (GRd) activity [exp(β) = 0.83, exp(β) = 0.72, respectively], and BPA was borderline associated to increased levels of oxidized glutathione (GSSG) [exp(β) = 1.73, p-value = 0.062]. MeP was inversely associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of thiobarbituric acid reactive substances (TBARS) [0.75 < exp(β) < 0.79]. Our results suggest that some specific non-persistent pollutants may be associated with a disruption of the activity of relevant antioxidant enzymes, in addition to the depletion of the glutathione stock. They might act as a tissue-specific source of free radicals, contributing to the oxidative microenvironment in the adipose tissue.

Original languageEnglish
Article number105118
JournalEnvironment International
Volume133
Issue numberPt A
Pages (from-to)105118
ISSN0160-4120
DOIs
Publication statusPublished - Dec 2019

ID: 58289635