TY - JOUR
T1 - Adenovirus Infections and Disease in Solid Organ Transplant Recipients
T2 - Incidence and Outcomes
AU - Grarup, Katrine Riishøj
AU - Schwartz Sørensen, Søren
AU - Perch, Michael
AU - Schultz, Nicolai
AU - Gustafsson, Finn
AU - Brix Christensen, Vibeke
AU - Schønning, Kristian
AU - Sommerlund Moestrup, Kasper
AU - Lundgren, Jens
AU - Crone, Cornelia Geisler
AU - Helleberg, Marie
N1 - © The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2025/2
Y1 - 2025/2
N2 - BACKGROUND: We aimed to examine the epidemiology and outcomes of AdV disease in SOTr and assess the utility of AdV surveillance in SOTr <13 years.METHODS: SOTr transplanted at Rigshospitalet, 2010-2021, were included. The center had a screening program for SOTr <13 years with monthly plasma AdV tests the first 6 months following transplantation.RESULTS: We included 2009 SOTr (of whom 82 were aged <13 years), and 1330 blood samples from 382 SOTr were analyzed for AdV, of which 10 (0.8%) from 6 SOTr <13 years tested positive. Five out of six were tested as part of the screening program. Three remained asymptomatic, while three had symptoms attributable to co-infections. One adult lung transplant recipient with AdV in BAL had acute exacerbation of chronic graft rejection.CONCLUSIONS: We found a low incidence of AdV disease. SOTr diagnosed with AdV viremia as part of screening remained asymptomatic or had symptoms attributable to co-infections. Our findings do not support routine surveillance for AdV in SOTr.
AB - BACKGROUND: We aimed to examine the epidemiology and outcomes of AdV disease in SOTr and assess the utility of AdV surveillance in SOTr <13 years.METHODS: SOTr transplanted at Rigshospitalet, 2010-2021, were included. The center had a screening program for SOTr <13 years with monthly plasma AdV tests the first 6 months following transplantation.RESULTS: We included 2009 SOTr (of whom 82 were aged <13 years), and 1330 blood samples from 382 SOTr were analyzed for AdV, of which 10 (0.8%) from 6 SOTr <13 years tested positive. Five out of six were tested as part of the screening program. Three remained asymptomatic, while three had symptoms attributable to co-infections. One adult lung transplant recipient with AdV in BAL had acute exacerbation of chronic graft rejection.CONCLUSIONS: We found a low incidence of AdV disease. SOTr diagnosed with AdV viremia as part of screening remained asymptomatic or had symptoms attributable to co-infections. Our findings do not support routine surveillance for AdV in SOTr.
UR - http://www.scopus.com/inward/record.url?scp=85217199801&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofaf032
DO - 10.1093/ofid/ofaf032
M3 - Journal article
C2 - 39917336
SN - 2328-8957
VL - 12
SP - ofaf032
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 2
M1 - ofaf032
ER -