Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics

Sara Linea Von Holstein; André Fehr; Marta Persson; Marianne H Therkildsen; Jan Ulrik Prause; Steffen Heegaard; Göran Stenman

doi:10.1016/j.ophtha.2013.03.030

Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics

Sara Linea Von Holstein, André Fehr, Marta Persson, Marianne H Therkildsen, Jan Ulrik Prause, Steffen Heegaard, Göran Stenman

65 Citations (Scopus)

Abstract

To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.

Original language	English
Journal	Ophthalmology
Volume	120
Issue number	10
Pages (from-to)	2130-8
Number of pages	9
ISSN	0161-6420
DOIs	https://doi.org/10.1016/j.ophtha.2013.03.030
Publication status	Published - Oct 2013

Keywords

Adult
Aged
Carcinoma, Adenoid Cystic
Eye Neoplasms
Female
Genes, myb
Humans
Immunohistochemistry
Lacrimal Apparatus Diseases
Male
Middle Aged
Oncogene Proteins, Fusion
Proto-Oncogene Proteins c-myb
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA

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10.1016/j.ophtha.2013.03.030

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@article{71edac705f694207b79b38047c3a93e4,

title = "Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics",

abstract = "To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.",

keywords = "Adult, Aged, Carcinoma, Adenoid Cystic, Eye Neoplasms, Female, Genes, myb, Humans, Immunohistochemistry, Lacrimal Apparatus Diseases, Male, Middle Aged, Oncogene Proteins, Fusion, Proto-Oncogene Proteins c-myb, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA",

author = "{Von Holstein}, {Sara Linea} and Andr{\'e} Fehr and Marta Persson and Therkildsen, {Marianne H} and Prause, {Jan Ulrik} and Steffen Heegaard and G{\"o}ran Stenman",

year = "2013",

month = oct,

doi = "10.1016/j.ophtha.2013.03.030",

language = "English",

volume = "120",

pages = "2130--8",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc",

number = "10",

}

TY - JOUR

T1 - Adenoid cystic carcinoma of the lacrimal gland

T2 - MYB gene activation, genomic imbalances, and clinical characteristics

AU - Von Holstein, Sara Linea

AU - Fehr, André

AU - Persson, Marta

AU - Therkildsen, Marianne H

AU - Prause, Jan Ulrik

AU - Heegaard, Steffen

AU - Stenman, Göran

PY - 2013/10

Y1 - 2013/10

N2 - To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.

AB - To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.

KW - Adult

KW - Aged

KW - Carcinoma, Adenoid Cystic

KW - Eye Neoplasms

KW - Female

KW - Genes, myb

KW - Humans

KW - Immunohistochemistry

KW - Lacrimal Apparatus Diseases

KW - Male

KW - Middle Aged

KW - Oncogene Proteins, Fusion

KW - Proto-Oncogene Proteins c-myb

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Sequence Analysis, DNA

U2 - 10.1016/j.ophtha.2013.03.030

DO - 10.1016/j.ophtha.2013.03.030

M3 - Journal article

C2 - 23725736

SN - 0161-6420

VL - 120

SP - 2130

EP - 2138

JO - Ophthalmology

JF - Ophthalmology

IS - 10

ER -

Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics

Abstract

Keywords

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