Addition of sunitinib to cetuximab and irinotecan in patients with heavily pre-treated advanced colorectal cancer

C. Qvortrup, B.V. Jensen, T.L. Jorgensen, Dorthe L. Nielsen, J.K. Bjerregaard, Per Pfeiffer

10 Citations (Scopus)

Abstract

Results of continuous sunitinib, in combination with cetuximab and irinotecan every other week ( SIC) for compassionate use in heavily pre-treated patients with mCRC are presented. Patients and methods. Patients with mCRC resistant to oxaliplatin, irinotecan, 5-FU and cetuximab received SIC at two Danish oncologic departments. The regimen consisted of sunitinib given as a continuous-dosing in combination with cetuximab and irinotecan every other week (CetIri). The first six patients started with a daily oral dose of sunitinib of 12.5 mg. Subsequent patients started at a daily dose of 25 mg with the possibility to escalate to 37.5 mg. Results. Twenty-nine patients received SIC. No patient had an objective response, but 13 patients had subjective relief and 42% had stable disease. The median time to progression was 3.2 months and median overall survival was 7.4 months. Fatigue and leukopenia were the most frequently reported severe adverse event (18% grade 3 and 18% grade 3/4, respectively). Discussion. Sunitinib continuous-dosing with 25 mg/day can safely be combined with CetIri administered every other week
Original languageEnglish
JournalActa Oncologica
Volume49
Issue number6
Pages (from-to)833-836
Number of pages4
ISSN0284-186X
DOIs
Publication statusPublished - 2010

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