Added diagnostic value of magnetoencephalography (MEG) in patients suspected for epilepsy, where previous, extensive EEG workup was unrevealing

Lene Duez; Sándor Beniczky; Hatice Tankisi; Peter Orm Hansen; Per Sidenius; Anne Sabers; Anders Fuglsang-Frederiksen

doi:10.1016/j.clinph.2016.08.006

Added diagnostic value of magnetoencephalography (MEG) in patients suspected for epilepsy, where previous, extensive EEG workup was unrevealing

Lene Duez, Sándor Beniczky, Hatice Tankisi, Peter Orm Hansen, Per Sidenius, Anne Sabers, Anders Fuglsang-Frederiksen

Department of Neurology

24 Citations (Scopus)

Abstract

OBJECTIVE: To elucidate the possible additional diagnostic yield of MEG in the workup of patients with suspected epilepsy, where repeated EEGs, including sleep-recordings failed to identify abnormalities.

METHODS: Fifty-two consecutive patients with clinical suspicion of epilepsy and at least three normal EEGs, including sleep-EEG, were prospectively analyzed. The reference standard was inferred from the diagnosis obtained from the medical charts, after at least one-year follow-up. MEG (306-channel, whole-head) and simultaneous EEG (MEG-EEG) was recorded for one hour. The added sensitivity of MEG was calculated from the cases where abnormalities were seen in MEG but not EEG.

RESULTS: Twenty-two patients had the diagnosis epilepsy according to the reference standard. MEG-EEG detected abnormalities, and supported the diagnosis in nine of the 22 patients with the diagnosis epilepsy at one-year follow-up. Sensitivity of MEG-EEG was 41%. The added sensitivity of MEG was 18%. MEG-EEG was normal in 28 of the 30 patients categorized as 'not epilepsy' at one year follow-up, yielding a specificity of 93%.

CONCLUSIONS: MEG provides additional diagnostic information in patients suspected for epilepsy, where repeated EEG recordings fail to demonstrate abnormality.

SIGNIFICANCE: MEG should be included in the diagnostic workup of patients where the conventional, widely available methods are unrevealing.

Original language	English
Journal	Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Volume	127
Issue number	10
Pages (from-to)	3301-5
Number of pages	5
ISSN	1388-2457
DOIs	https://doi.org/10.1016/j.clinph.2016.08.006
Publication status	Published - Oct 2016

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Journal Article

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10.1016/j.clinph.2016.08.006

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Duez, L., Beniczky, S., Tankisi, H., Hansen, P. O., Sidenius, P., Sabers, A., & Fuglsang-Frederiksen, A. (2016). Added diagnostic value of magnetoencephalography (MEG) in patients suspected for epilepsy, where previous, extensive EEG workup was unrevealing. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 127(10), 3301-5. https://doi.org/10.1016/j.clinph.2016.08.006

Added diagnostic value of magnetoencephalography (MEG) in patients suspected for epilepsy, where previous, extensive EEG workup was unrevealing. / Duez, Lene; Beniczky, Sándor; Tankisi, Hatice et al.
In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Vol. 127, No. 10, 10.2016, p. 3301-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Duez, L, Beniczky, S, Tankisi, H, Hansen, PO, Sidenius, P, Sabers, A & Fuglsang-Frederiksen, A 2016, 'Added diagnostic value of magnetoencephalography (MEG) in patients suspected for epilepsy, where previous, extensive EEG workup was unrevealing', Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, vol. 127, no. 10, pp. 3301-5. https://doi.org/10.1016/j.clinph.2016.08.006

Duez L, Beniczky S, Tankisi H, Hansen PO, Sidenius P, Sabers A et al. Added diagnostic value of magnetoencephalography (MEG) in patients suspected for epilepsy, where previous, extensive EEG workup was unrevealing. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2016 Oct;127(10):3301-5. doi: 10.1016/j.clinph.2016.08.006

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AU - Sidenius, Per

AU - Sabers, Anne

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Added diagnostic value of magnetoencephalography (MEG) in patients suspected for epilepsy, where previous, extensive EEG workup was unrevealing

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