Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: Adaptive trial design was developed initially for oncology to improve trial efficiency. If optimized for rheumatology, it may improve trial efficiency by reducing sample size and time.
METHODS: A systematic review assessed design of phase II clinical trials in rheumatoid arthritis.
RESULTS: Fifty-six trials were reviewed. Most trials had 4 groups (1 control and 3 intervention), with an average group size of 34 patients. American College of Rheumatology 20 measured at 16 weeks was the most commonly used primary endpoint.
CONCLUSION: The next step is to undertake a systematic review of adaptive designs used in early-phase trials in nonrheumatic conditions.
Original language | English |
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Journal | Journal of Rheumatology |
Volume | 46 |
Issue number | 10 |
Pages (from-to) | 1406-1408 |
Number of pages | 3 |
ISSN | 0315-162X |
DOIs | |
Publication status | Published - Oct 2019 |
ID: 58098123