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Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

Research output: Contribution to journalJournal articleResearchpeer-review


  • Tim Pickles
  • Rieke Alten
  • Maarten Boers
  • Vivian Bykerk
  • Jared Christensen
  • Robin Christensen
  • Hubert van Hoogstraten
  • Lee S Simon
  • Lai-Shan Tam
  • Ernest H Choy
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OBJECTIVE: Adaptive trial design was developed initially for oncology to improve trial efficiency. If optimized for rheumatology, it may improve trial efficiency by reducing sample size and time.

METHODS: A systematic review assessed design of phase II clinical trials in rheumatoid arthritis.

RESULTS: Fifty-six trials were reviewed. Most trials had 4 groups (1 control and 3 intervention), with an average group size of 34 patients. American College of Rheumatology 20 measured at 16 weeks was the most commonly used primary endpoint.

CONCLUSION: The next step is to undertake a systematic review of adaptive designs used in early-phase trials in nonrheumatic conditions.

Original languageEnglish
JournalJournal of Rheumatology
Issue number10
Pages (from-to)1406-1408
Number of pages3
Publication statusPublished - Oct 2019

    Research areas

  • Adaptive trial design, Early-phase clinical trial, Omeract core outcome set, Rheumatoid arthritis, Systematic review

ID: 58098123