Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report

Josefine Windfeld-Mathiasen; Henrik Horwitz; Frederik Schwartz

doi:10.2106/JBJS.CC.22.00621

Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report

Josefine Windfeld-Mathiasen^*, Henrik Horwitz, Frederik Schwartz

^*Corresponding author for this work

1 Citation (Scopus)

Abstract

CASE: A 50-year-old healthy man with normal kidney function underwent surgery for fracture-related infection. Unfortunately, the patient received 2.5 times the intended dose of tobramycin pellets in the medullary cavity and developed acute kidney failure. Given the intraosseous administration of tobramycin, the drug displayed an absorption-dependent pharmacokinetics and multiple treatments with hemodialysis were needed. However, the patient had a complete recovery, and the kidney function remained normal at the 2-year follow-up.

CONCLUSION: Tobramycin pellets are nephrotoxic in supratherapeutic doses; however, it was reversible in this case. Owing to the intraosseous administration, multiple treatments with hemodialysis were required.

Original language	English
Article number	e22.00621
Journal	JBJS case connector
Volume	13
Issue number	2
ISSN	2160-3251
DOIs	https://doi.org/10.2106/JBJS.CC.22.00621
Publication status	Published - 1 Apr 2023

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title = "Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report",

abstract = "CASE: A 50-year-old healthy man with normal kidney function underwent surgery for fracture-related infection. Unfortunately, the patient received 2.5 times the intended dose of tobramycin pellets in the medullary cavity and developed acute kidney failure. Given the intraosseous administration of tobramycin, the drug displayed an absorption-dependent pharmacokinetics and multiple treatments with hemodialysis were needed. However, the patient had a complete recovery, and the kidney function remained normal at the 2-year follow-up.CONCLUSION: Tobramycin pellets are nephrotoxic in supratherapeutic doses; however, it was reversible in this case. Owing to the intraosseous administration, multiple treatments with hemodialysis were required.",

author = "Josefine Windfeld-Mathiasen and Henrik Horwitz and Frederik Schwartz",

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T1 - Acute Kidney Injury because of Implanted Tobramycin Pellets

T2 - A Case Report

AU - Windfeld-Mathiasen, Josefine

AU - Horwitz, Henrik

AU - Schwartz, Frederik

PY - 2023/4/1

Y1 - 2023/4/1

N2 - CASE: A 50-year-old healthy man with normal kidney function underwent surgery for fracture-related infection. Unfortunately, the patient received 2.5 times the intended dose of tobramycin pellets in the medullary cavity and developed acute kidney failure. Given the intraosseous administration of tobramycin, the drug displayed an absorption-dependent pharmacokinetics and multiple treatments with hemodialysis were needed. However, the patient had a complete recovery, and the kidney function remained normal at the 2-year follow-up.CONCLUSION: Tobramycin pellets are nephrotoxic in supratherapeutic doses; however, it was reversible in this case. Owing to the intraosseous administration, multiple treatments with hemodialysis were required.

AB - CASE: A 50-year-old healthy man with normal kidney function underwent surgery for fracture-related infection. Unfortunately, the patient received 2.5 times the intended dose of tobramycin pellets in the medullary cavity and developed acute kidney failure. Given the intraosseous administration of tobramycin, the drug displayed an absorption-dependent pharmacokinetics and multiple treatments with hemodialysis were needed. However, the patient had a complete recovery, and the kidney function remained normal at the 2-year follow-up.CONCLUSION: Tobramycin pellets are nephrotoxic in supratherapeutic doses; however, it was reversible in this case. Owing to the intraosseous administration, multiple treatments with hemodialysis were required.

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DO - 10.2106/JBJS.CC.22.00621

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JO - JBJS case connector

JF - JBJS case connector

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ER -

Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report

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