Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Abdellatif El-Ahmadi; Mujahed Sebastian Abassi; Hedvig Bille Andersson; Thomas Engstrøm; Peter Clemmensen; Steffen Helqvist; Erik Jørgensen; Henning Kelbæk; Frants Pedersen; Kari Saunamäki; Jacob Lønborg; Lene Holmvang

doi:10.1371/journal.pone.0226625

Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Abdellatif El-Ahmadi, Mujahed Sebastian Abassi, Hedvig Bille Andersson, Thomas Engstrøm, Peter Clemmensen, Steffen Helqvist, Erik Jørgensen, Henning Kelbæk, Frants Pedersen, Kari Saunamäki, Jacob Lønborg, Lene Holmvang

Department of Cardiology

Abstract

OBJECTIVES: The aim of the study was to investigate the incidence, risk factors and long-term prognosis of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (primary PCI).

METHOD: A large-scale, retrospective cohort study based on procedure-related variables, biochemical and mortality data collected between 2009 and 2014 at Rigshospitalet, Copenhagen, Denmark. AKI was defined as an increase in serum creatinine of 25% during the first 72 hours after the index procedure.

RESULTS: A total of 4239 patients were treated with primary PCI of whom 4002 had available creatinine measurements allowing for assessment of AKI and inclusion in this study. The mean creatinine value upon presentation for all patients was 84 μmol/l (standard deviation (SD) ±40) and 97 μmol/l (SD ±53) at peak. AKI occurred in a total of 765 (19.1%) patients. Independent risk factors for the occurrence of AKI were age, time from symptom onset to procedure, peak value of troponin-T, female sex and the contrast volume to eGFR ratio. In a multivariable adjusted analysis AKI was independently associated with a higher mortality rate at 5 years follow-up (hazard ratio 1.39 [95%-confidence interval 1.03-1.88]).

CONCLUSION: In STEMI patients treated with primary PCI one in five experiences acute kidney injury, which was associated with a substantial increase in both short- and long-term mortality.

Original language	English
Journal	PLoS One
Volume	14
Issue number	12
Pages (from-to)	e0226625
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0226625
Publication status	Published - 2019

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El-Ahmadi, A., Abassi, M. S., Andersson, H. B., Engstrøm, T., Clemmensen, P., Helqvist, S., Jørgensen, E., Kelbæk, H., Pedersen, F., Saunamäki, K., Lønborg, J., & Holmvang, L. (2019). Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. PLoS One, 14(12), e0226625. https://doi.org/10.1371/journal.pone.0226625

Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. / El-Ahmadi, Abdellatif; Abassi, Mujahed Sebastian; Andersson, Hedvig Bille et al.
In: PLoS One, Vol. 14, No. 12, 2019, p. e0226625.

Research output: Contribution to journal › Journal article › Research › peer-review

El-Ahmadi, A, Abassi, MS, Andersson, HB , Engstrøm, T, Clemmensen, P, Helqvist, S , Jørgensen, E, Kelbæk, H, Pedersen, F, Saunamäki, K, Lønborg, J & Holmvang, L 2019, 'Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction', PLoS One, vol. 14, no. 12, pp. e0226625. https://doi.org/10.1371/journal.pone.0226625

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abstract = "OBJECTIVES: The aim of the study was to investigate the incidence, risk factors and long-term prognosis of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (primary PCI).METHOD: A large-scale, retrospective cohort study based on procedure-related variables, biochemical and mortality data collected between 2009 and 2014 at Rigshospitalet, Copenhagen, Denmark. AKI was defined as an increase in serum creatinine of 25% during the first 72 hours after the index procedure.RESULTS: A total of 4239 patients were treated with primary PCI of whom 4002 had available creatinine measurements allowing for assessment of AKI and inclusion in this study. The mean creatinine value upon presentation for all patients was 84 μmol/l (standard deviation (SD) ±40) and 97 μmol/l (SD ±53) at peak. AKI occurred in a total of 765 (19.1%) patients. Independent risk factors for the occurrence of AKI were age, time from symptom onset to procedure, peak value of troponin-T, female sex and the contrast volume to eGFR ratio. In a multivariable adjusted analysis AKI was independently associated with a higher mortality rate at 5 years follow-up (hazard ratio 1.39 [95%-confidence interval 1.03-1.88]).CONCLUSION: In STEMI patients treated with primary PCI one in five experiences acute kidney injury, which was associated with a substantial increase in both short- and long-term mortality.",

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T1 - Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

AU - El-Ahmadi, Abdellatif

AU - Abassi, Mujahed Sebastian

AU - Andersson, Hedvig Bille

AU - Engstrøm, Thomas

AU - Clemmensen, Peter

AU - Helqvist, Steffen

AU - Jørgensen, Erik

AU - Kelbæk, Henning

AU - Pedersen, Frants

AU - Saunamäki, Kari

AU - Lønborg, Jacob

AU - Holmvang, Lene

PY - 2019

Y1 - 2019

N2 - OBJECTIVES: The aim of the study was to investigate the incidence, risk factors and long-term prognosis of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (primary PCI).METHOD: A large-scale, retrospective cohort study based on procedure-related variables, biochemical and mortality data collected between 2009 and 2014 at Rigshospitalet, Copenhagen, Denmark. AKI was defined as an increase in serum creatinine of 25% during the first 72 hours after the index procedure.RESULTS: A total of 4239 patients were treated with primary PCI of whom 4002 had available creatinine measurements allowing for assessment of AKI and inclusion in this study. The mean creatinine value upon presentation for all patients was 84 μmol/l (standard deviation (SD) ±40) and 97 μmol/l (SD ±53) at peak. AKI occurred in a total of 765 (19.1%) patients. Independent risk factors for the occurrence of AKI were age, time from symptom onset to procedure, peak value of troponin-T, female sex and the contrast volume to eGFR ratio. In a multivariable adjusted analysis AKI was independently associated with a higher mortality rate at 5 years follow-up (hazard ratio 1.39 [95%-confidence interval 1.03-1.88]).CONCLUSION: In STEMI patients treated with primary PCI one in five experiences acute kidney injury, which was associated with a substantial increase in both short- and long-term mortality.

AB - OBJECTIVES: The aim of the study was to investigate the incidence, risk factors and long-term prognosis of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (primary PCI).METHOD: A large-scale, retrospective cohort study based on procedure-related variables, biochemical and mortality data collected between 2009 and 2014 at Rigshospitalet, Copenhagen, Denmark. AKI was defined as an increase in serum creatinine of 25% during the first 72 hours after the index procedure.RESULTS: A total of 4239 patients were treated with primary PCI of whom 4002 had available creatinine measurements allowing for assessment of AKI and inclusion in this study. The mean creatinine value upon presentation for all patients was 84 μmol/l (standard deviation (SD) ±40) and 97 μmol/l (SD ±53) at peak. AKI occurred in a total of 765 (19.1%) patients. Independent risk factors for the occurrence of AKI were age, time from symptom onset to procedure, peak value of troponin-T, female sex and the contrast volume to eGFR ratio. In a multivariable adjusted analysis AKI was independently associated with a higher mortality rate at 5 years follow-up (hazard ratio 1.39 [95%-confidence interval 1.03-1.88]).CONCLUSION: In STEMI patients treated with primary PCI one in five experiences acute kidney injury, which was associated with a substantial increase in both short- and long-term mortality.

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DO - 10.1371/journal.pone.0226625

M3 - Journal article

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SN - 1932-6203

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SP - e0226625

JO - PLoS One

JF - PLoS One

IS - 12

ER -

Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Abstract

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