Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Acute exercise protects newly formed motor memories against rTMS-induced interference targeting primary motor cortex

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Progressive effects of sildenafil on visual processing in rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Transcranial Alternating Current Stimulation Has Frequency-Dependent Effects on Motor Learning in Healthy Humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Functional Neuroimaging in Disorders of Consciousness: Raising Awareness for Those with Decreased Awareness

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Guidelines for TMS/tES Clinical Services and Research through the COVID-19 Pandemic

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Direct exposure of the head to solar heat radiation impairs motor-cognitive performance

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Mikkel Malling Beck
  • Marcus Udsen Grandjean
  • Sander Hartmand
  • Meaghan Elizabeth Spedden
  • Lasse Christiansen
  • Marc Roig
  • Jesper Lundbye-Jensen
View graph of relations

Acute cardiovascular exercise can promote motor memory consolidation following motor practice, and thus long-term retention, but the underlying mechanisms remain sparsely elucidated. Here we test the hypothesis that the positive behavioral effects of acute exercise involve the primary motor cortex and the corticospinal pathway by interfering with motor memory consolidation using non-invasive, low frequency, repetitive transcranial magnetic stimulation (rTMS). Forty-eight able-bodied, young adult male participants (mean age = 24.8 y/o) practiced a visuomotor accuracy task demanding precise and fast pinch force control. Following motor practice, participants either rested or exercised (20 min total: 3 × 3 min at 90% VO 2peak) before receiving either sham rTMS or supra-threshold rTMS (115% RMT, 1 Hz) targeting the hand area of the contralateral primary motor cortex for 20 min. Retention was evaluated 24 h following motor practice, and motor memory consolidation was operationalized as overnight changes in motor performance. Low-frequency rTMS resulted in off-line decrements in motor performance compared to sham rTMS, but these were counteracted by a preceding bout of intense exercise. These findings demonstrate that a single session of exercise promotes early motor memory stabilization and protects the primary motor cortex and the corticospinal system against interference.

Original languageEnglish
JournalNeuroscience
Volume436
Pages (from-to)110-121
Number of pages12
ISSN0306-4522
DOIs
Publication statusPublished - 1 Jun 2020

    Research areas

  • memory interference, motor learning, neuroplasticity, physical activity, skill learning

ID: 59699207