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Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review

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  3. The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine

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  2. Investigation of sumatriptan and ketorolac trometamol in the human experimental model of headache

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BACKGROUND: Post-traumatic headache (PTH) is associated with considerable disability and reduced health-related quality of life. Despite the very high prevalence of PTH, there are no evidence-based guidelines for PTH treatment. Thus, we found it timely to provide a systematic review of the current literature on acute and preventive pharmacological treatment of PTH using PubMed and Embase databases.

FINDINGS: Included studies involved acute and preventive pharmacological treatment of headache attributed to traumatic injury to the head in adherence to the International Classification of Headache Disorders (ICHD) criteria. Of 1424 potentially relevant articles identified, 63 were retrieved for detailed evaluation and seven studies (one prospective and six retrospective) met the inclusion criteria. None of the seven included studies were randomized clinical trials (RCTs) or used a placebo-controlled study design.

CONCLUSION: We found that there is a lack of high-quality evidence-based studies on the pharmacological treatment of PTH. Future studies are highly needed and must emphasize open-label studies with rigorous methodology or RCTs with a placebo-controlled design.

Original languageEnglish
JournalJournal of Headache and Pain
Volume20
Issue number1
Pages (from-to)98
ISSN1129-2377
DOIs
Publication statusPublished - 2019

    Research areas

  • Analgesics, Opioid/therapeutic use, Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, Humans, Post-Traumatic Headache/diagnosis, Prevalence, Prospective Studies, Quality of Life, Retrospective Studies, Treatment Outcome

ID: 59061970