Activated T lymphocytes disappear from circulation during endotoxemia in humans

K S Krabbe; H Bruunsgaard; J Qvist; L Fonsmark; K Møller; C M Hansen; P Skinhøj; B K Pedersen

doi:10.1128/cdli.9.3.731-735.2002

Activated T lymphocytes disappear from circulation during endotoxemia in humans

K S Krabbe, H Bruunsgaard, J Qvist, L Fonsmark, K Møller, C M Hansen, P Skinhøj, B K Pedersen

23 Citations (Scopus)

Abstract

Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

Original language	English
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	9
Issue number	3
Pages (from-to)	731-5
Number of pages	5
ISSN	1071-412X
DOIs	https://doi.org/10.1128/cdli.9.3.731-735.2002
Publication status	Published - May 2002
Externally published	Yes

Keywords

Adult
Aged
Aging/immunology
Apoptosis/immunology
CD28 Antigens/immunology
CD4-Positive T-Lymphocytes/immunology
CD8-Positive T-Lymphocytes/immunology
Endotoxemia/immunology
Escherichia coli
Humans
Killer Cells, Natural/immunology
Leukocyte Common Antigens/immunology
Lymphocyte Activation/immunology
Lymphopenia/immunology
Middle Aged
fas Receptor/immunology

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10.1128/cdli.9.3.731-735.2002

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title = "Activated T lymphocytes disappear from circulation during endotoxemia in humans",

abstract = "Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.",

keywords = "Adult, Aged, Aging/immunology, Apoptosis/immunology, CD28 Antigens/immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Endotoxemia/immunology, Escherichia coli, Humans, Killer Cells, Natural/immunology, Leukocyte Common Antigens/immunology, Lymphocyte Activation/immunology, Lymphopenia/immunology, Middle Aged, fas Receptor/immunology",

author = "Krabbe, \{K S\} and H Bruunsgaard and J Qvist and L Fonsmark and K M{\o}ller and Hansen, \{C M\} and P Skinh{\o}j and Pedersen, \{B K\}",

year = "2002",

month = may,

doi = "10.1128/cdli.9.3.731-735.2002",

language = "English",

volume = "9",

pages = "731--5",

journal = "Clinical and Diagnostic Laboratory Immunology",

issn = "1071-412X",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Activated T lymphocytes disappear from circulation during endotoxemia in humans

AU - Krabbe, K S

AU - Bruunsgaard, H

AU - Qvist, J

AU - Fonsmark, L

AU - Møller, K

AU - Hansen, C M

AU - Skinhøj, P

AU - Pedersen, B K

PY - 2002/5

Y1 - 2002/5

N2 - Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

AB - Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

KW - Adult

KW - Aged

KW - Aging/immunology

KW - Apoptosis/immunology

KW - CD28 Antigens/immunology

KW - CD4-Positive T-Lymphocytes/immunology

KW - CD8-Positive T-Lymphocytes/immunology

KW - Endotoxemia/immunology

KW - Escherichia coli

KW - Humans

KW - Killer Cells, Natural/immunology

KW - Leukocyte Common Antigens/immunology

KW - Lymphocyte Activation/immunology

KW - Lymphopenia/immunology

KW - Middle Aged

KW - fas Receptor/immunology

UR - https://www.scopus.com/pages/publications/0036111840

U2 - 10.1128/cdli.9.3.731-735.2002

DO - 10.1128/cdli.9.3.731-735.2002

M3 - Journal article

C2 - 11986289

SN - 1071-412X

VL - 9

SP - 731

EP - 735

JO - Clinical and Diagnostic Laboratory Immunology

JF - Clinical and Diagnostic Laboratory Immunology

IS - 3

ER -

Activated T lymphocytes disappear from circulation during endotoxemia in humans

Abstract

Keywords

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