Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

Jakob G Jespersen; Anders Nedergaard; Søren Reitelseder; Ulla R Mikkelsen; Kasper J Dideriksen; Jakob Agergaard; Frederik Kreiner; Frank C Pott; Peter Schjerling; Michael Kjaer

doi:10.1371/journal.pone.0018090

Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

Jakob G Jespersen, Anders Nedergaard, Søren Reitelseder, Ulla R Mikkelsen, Kasper J Dideriksen, Jakob Agergaard, Frederik Kreiner, Frank C Pott, Peter Schjerling, Michael Kjaer

41 Citations (Scopus)

Abstract

Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the phosphorylation and expression of key factors in these protein synthesis and breakdown signaling pathways in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with healthy controls.

Original language	English
Journal	P L o S One
Volume	6
Issue number	3
Pages (from-to)	e18090
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0018090
Publication status	Published - 2011

Keywords

Adult
Aged
Blotting, Western
Case-Control Studies
Critical Illness
Female
Humans
Male
Middle Aged
Muscle Proteins
Muscle, Skeletal
Protein Biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction

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abstract = "Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the phosphorylation and expression of key factors in these protein synthesis and breakdown signaling pathways in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with healthy controls.",

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T1 - Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

AU - Jespersen, Jakob G

AU - Nedergaard, Anders

AU - Reitelseder, Søren

AU - Mikkelsen, Ulla R

AU - Dideriksen, Kasper J

AU - Agergaard, Jakob

AU - Kreiner, Frederik

AU - Pott, Frank C

AU - Schjerling, Peter

AU - Kjaer, Michael

PY - 2011

Y1 - 2011

N2 - Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the phosphorylation and expression of key factors in these protein synthesis and breakdown signaling pathways in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with healthy controls.

AB - Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the phosphorylation and expression of key factors in these protein synthesis and breakdown signaling pathways in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with healthy controls.

KW - Adult

KW - Aged

KW - Blotting, Western

KW - Case-Control Studies

KW - Critical Illness

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Muscle Proteins

KW - Muscle, Skeletal

KW - Protein Biosynthesis

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Signal Transduction

U2 - 10.1371/journal.pone.0018090

DO - 10.1371/journal.pone.0018090

M3 - Journal article

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SN - 1932-6203

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SP - e18090

JO - P L o S One

JF - P L o S One

IS - 3

ER -

Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

Abstract

Keywords

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