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Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

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Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets activated by thrombin-receptor-activating peptide enhanced IL-10 production induced by LPS (p
Original languageEnglish
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume191
Issue number8
Pages (from-to)4059-67
Number of pages9
ISSN0022-1767
DOIs
Publication statusPublished - 15 Oct 2013

    Research areas

  • Antigens, CD40, Blood Platelets, CD4-Positive T-Lymphocytes, CD40 Ligand, Cell Proliferation, Cells, Cultured, Humans, Inflammation, Interleukin-10, Lipopolysaccharides, Monocytes, Platelet Activation, Porphyromonas gingivalis, Tetanus Toxin, Thyroglobulin, Tumor Necrosis Factor-alpha

ID: 42807074